2'-Fluoro-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H12FN5O3
- MW
- 269.23
- Purity
- 99.2% (HPLC)
2'-Fluoro-2'-deoxyadenosine (2'-F-dA) is an adenosine analog in which the 2'-hydroxyl of the sugar is replaced by fluorine. CH64025 is identified by CAS 64183-27-3, molecular formula C10H12FN5O3, molecular weight 269.23, and PubChem CID 100253.
The cited oligonucleotide literature discusses 2'-fluoro modifications in siRNA and antisense research for nuclease resistance and binding affinity. CH64025 provides the adenine 2'-fluoro-2'-deoxy nucleoside identity for related oligonucleotide-modification studies.
Synonyms
2'-Fluoro-2'-deoxyadenosine; 2'-F-dA; 2'-F-A
Identity and specifications
| Catalog No. | CH64025 |
| CAS No. | 64183-27-3 |
| Molecular Formula | C10H12FN5O3 |
| Molecular Weight | 269.23 |
| PubChem CID | 100253 |
| InChIKey | ZGYYPTJWJBEXBC-QYYRPYCUSA-N |
| Purity | 99.2% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Adenine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Nucleoside class
- 2'-Fluoro purine nucleoside
- Packaging
- Custom packaging on request
- Water content
- 0.08% w/w by KF
- Physical form
- White, fluffy powder
- Stability
- >=4 years
Application context
- 2'-F oligonucleotide research: CH64025 is relevant to siRNA and antisense modification studies involving 2'-fluoro adenine residues.
- Modified-nucleic-acid studies: the 2'-fluoro motif is discussed in duplex-affinity and nuclease-resistance research on modified oligonucleotides.
- 2'-F nucleoside reference: CH64025 provides the 2'-fluoro-2'-deoxyadenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 100253
PubChem · CID 100253
Frequently Asked Questions
How is 2'-F-dA different from 2'-deoxyadenosine?
2'-Deoxyadenosine has a hydrogen at the 2' position; 2'-fluoro-2'-deoxyadenosine has a fluorine there. 2'-deoxyadenosine is cataloged separately.
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