2'-Fluoro-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C9H12FN3O4
- MW
- 245.21
- Purity
- >98.0% (titration)
2'-Fluoro-2'-deoxycytidine (2'-F-dC) is a cytidine analog in which the 2'-hydroxyl of the sugar is replaced by fluorine. CH64026 is identified by CAS 10212-20-1, molecular formula C9H12FN3O4, molecular weight 245.21, and PubChem CID 101507.
The cited oligonucleotide literature discusses 2'-fluoro modifications in siRNA and antisense research for nuclease resistance and binding affinity. CH64026 provides the cytidine 2'-fluoro-2'-deoxy nucleoside identity for related oligonucleotide-modification studies.
Synonyms
2'-Fluoro-2'-deoxycytidine; 2'-F-dC; 2'-F-C
Identity and specifications
| Catalog No. | CH64026 |
| CAS No. | 10212-20-1 |
| Molecular Formula | C9H12FN3O4 |
| Molecular Weight | 245.21 |
| PubChem CID | 101507 |
| InChIKey | NVZFZMCNALTPBY-XVFCMESISA-N |
| Purity | >98.0% (titration) |
Storage conditions
Room temperature; cool and dark below 15 C
Technical attributes
- Nucleobase
- Cytosine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Nucleoside class
- 2'-Fluoro pyrimidine nucleoside
- Packaging
- 1 g glass bottle with plastic insert; Custom packaging on request
- Water content
- <=10.0%
- Physical form
- Solid; white to almost white powder to crystal
Application context
- 2'-F oligonucleotide research: CH64026 is relevant to siRNA and antisense modification studies involving 2'-fluoro cytidine residues.
- Modified-nucleic-acid studies: the 2'-fluoro motif is discussed in duplex-affinity and nuclease-resistance research on modified oligonucleotides.
- 2'-F nucleoside reference: CH64026 provides the 2'-fluoro-2'-deoxycytidine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 101507
PubChem · CID 101507
Frequently Asked Questions
How is 2'-F-dC different from 2'-deoxycytidine?
2'-Deoxycytidine has a hydrogen at the 2' position; 2'-fluoro-2'-deoxycytidine has a fluorine there. 2'-deoxycytidine is cataloged separately.
Similar Products
Need Help with Material Selection?
CHEMOS can review product fit, target structure, route questions, analytical expectations, and project-specific supply needs.