2'-Fluoro-2'-deoxyuridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C9H11FN2O5
- MW
- 246.19
- Purity
- >=99.0% (HPLC)
2'-Fluoro-2'-deoxyuridine (2'-F-dU) is a uridine analog in which the 2'-hydroxyl of the sugar is replaced by fluorine. CH64028 is identified by CAS 784-71-4, molecular formula C9H11FN2O5, molecular weight 246.19, and PubChem CID 150851. The fluorine is on the sugar, which distinguishes CH64028 from base-fluorinated 5-fluoro uridine derivatives.
The cited oligonucleotide literature discusses 2'-fluoro modifications in siRNA and antisense research for nuclease resistance and binding affinity. CH64028 provides the uridine 2'-fluoro-2'-deoxy nucleoside identity for related oligonucleotide-modification studies.
Synonyms
2'-Fluoro-2'-deoxyuridine; 2'-F-dU; 2'-F-U
Identity and specifications
| Catalog No. | CH64028 |
| CAS No. | 784-71-4 |
| Molecular Formula | C9H11FN2O5 |
| Molecular Weight | 246.19 |
| PubChem CID | 150851 |
| InChIKey | UIYWFOZZIZEEKJ-XVFCMESISA-N |
| Purity | >=99.0% (HPLC) |
Storage conditions
4 C
Technical attributes
- Nucleobase
- Uracil
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Nucleoside class
- 2'-Fluoro pyrimidine nucleoside
- Packaging
- Custom packaging on request
- Water content
- <=3.0% KF
- Physical form
- White crystalline powder
- Stability
- >=4 years
Application context
- 2'-F oligonucleotide research: CH64028 is relevant to siRNA and antisense modification studies involving 2'-fluoro uridine residues.
- Modified-nucleic-acid studies: the 2'-fluoro motif is discussed in duplex-affinity and nuclease-resistance research on modified oligonucleotides.
- 2'-F nucleoside reference: CH64028 provides the 2'-fluoro-2'-deoxyuridine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 150851
PubChem · CID 150851
Frequently Asked Questions
Is this 2'-fluoro or 5-fluoro uridine?
It is 2'-fluoro-2'-deoxyuridine — the fluorine is on the 2' position of the sugar. It is different from 5-fluoro uridine derivatives, where the fluorine is on the uracil base.
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