2'-O-(2-Methoxyethyl)-5-methylcytidine
4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidin-2-one
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidin-2-one
- MF
- C13H21N3O6
- MW
- 315.32
- Purity
- >=98% (HPLC)
2'-O-(2-Methoxyethyl)-5-methylcytidine (2'-O-MOE-5-Me-C) is 5-methylcytidine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64030 is identified by CAS 244105-55-3, molecular formula C13H21N3O6, molecular weight 315.32, and PubChem CID 18345944.
In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64030 provides the corrected 2'-O-MOE-5-methylcytidine identity for related antisense-oligonucleotide research.
Synonyms
2'-O-(2-Methoxyethyl)-5-methylcytidine; 2'-O-MOE-5-Me-C; MOE-5-methyl-C
Identity and specifications
| Catalog No. | CH64030 |
| CAS No. | 244105-55-3 |
| Molecular Formula | C13H21N3O6 |
| Molecular Weight | 315.32 |
| PubChem CID | 18345944 |
| InChIKey | GUEIFVRYWPOXHJ-DNRKLUKYSA-N |
| Purity | >=98% (HPLC) |
Storage conditions
2-8 C
Technical attributes
- Nucleobase
- 5-Methylcytosine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Nucleoside class
- MOE-modified pyrimidine ribonucleoside
- Packaging
- 500 mg; 1 g; 2 g; 5 g; Custom packaging on request
- Water content
- <=7% KF
- Physical form
- Powder; white to off-white
Application context
- MOE gapmer antisense research: CH64030 is relevant to gapmer antisense studies involving 2'-O-MOE 5-methyl-C residues.
- Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
- MOE nucleoside reference: CH64030 provides the 2'-O-(2-methoxyethyl)-5-methylcytidine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 18345944
PubChem · CID 18345944
Frequently Asked Questions
Is CH64030 a uridine or a cytidine?
CH64030 is a cytidine derivative: it has a 5-methylcytosine base and a 2'-O-(2-methoxyethyl) ribose modification.
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