2'-O-(2-Methoxyethyl)guanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C13H19N5O6
- MW
- 341.32
- Purity
- >=98%
2'-O-(2-Methoxyethyl)guanosine (2'-O-MOE-G) is guanosine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64031 is identified by CAS 473278-54-5, molecular formula C13H19N5O6, molecular weight 341.32, and PubChem CID 135544588.
In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64031 provides the guanosine 2'-O-MOE nucleoside identity for related antisense-oligonucleotide research.
Synonyms
2'-O-(2-Methoxyethyl)guanosine; 2'-O-MOE-G; 2'-MOE-G
Identity and specifications
| Catalog No. | CH64031 |
| CAS No. | 473278-54-5 |
| Molecular Formula | C13H19N5O6 |
| Molecular Weight | 341.32 |
| PubChem CID | 135544588 |
| InChIKey | DLLBJSLIKOKFHE-WOUKDFQISA-N |
| Purity | >=98% |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Guanine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Nucleoside class
- MOE-modified purine ribonucleoside
- Packaging
- Custom packaging on request
- Physical form
- Solid
- Stability
- >=4 years
Application context
- MOE gapmer antisense research: CH64031 is relevant to gapmer antisense studies involving 2'-O-MOE guanine residues.
- Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
- 2'-O-MOE nucleoside reference: CH64031 provides the 2'-O-(2-methoxyethyl)guanosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135544588
PubChem · CID 135544588
Frequently Asked Questions
How is 2'-O-MOE-guanosine different from 2'-O-methylguanosine?
Both are 2'-O-alkyl modifications, but MOE is a larger 2-methoxyethyl group versus a single methyl in 2'-O-methyl. 2'-O-methylguanosine is cataloged separately.
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