2'-O-(2-Methoxyethyl)-5-methyluridine
1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
- MF
- C13H20N2O7
- MW
- 316.31
- Purity
- >=98%
2'-O-(2-Methoxyethyl)-5-methyluridine (2'-O-MOE-5-Me-U), also called 2'-O-MOE ribothymidine, is 5-methyluridine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64032 is identified by CAS 163759-49-7, molecular formula C13H20N2O7, molecular weight 316.31, and PubChem CID 11243988.
In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64032 provides the 2'-O-MOE-5-methyluridine identity for related antisense-oligonucleotide research.
Synonyms
2'-O-(2-Methoxyethyl)-5-methyluridine; 2'-O-MOE-5-Me-U; 2'-O-MOE-ribothymidine
Identity and specifications
| Catalog No. | CH64032 |
| CAS No. | 163759-49-7 |
| Molecular Formula | C13H20N2O7 |
| Molecular Weight | 316.31 |
| PubChem CID | 11243988 |
| InChIKey | NEVQCHBUJFYGQO-DNRKLUKYSA-N |
| Purity | >=98% |
Storage conditions
2-8 C
Technical attributes
- Nucleobase
- 5-Methyluracil
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Nucleoside class
- MOE-modified pyrimidine ribonucleoside
- Packaging
- Custom packaging on request
- Physical form
- White to off-white powder
Application context
- MOE gapmer antisense research: CH64032 is relevant to gapmer antisense studies involving 2'-O-MOE 5-methyl-U residues.
- Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
- 2'-O-MOE nucleoside reference: CH64032 provides the 2'-O-(2-methoxyethyl)-5-methyluridine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 11243988
PubChem · CID 11243988
Frequently Asked Questions
What nucleobase does CH64032 contain?
CH64032 is a 5-methyluridine derivative: it has a 5-methyluracil base and a 2'-O-(2-methoxyethyl) ribose modification.
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