2'-O-(2-Methoxyethyl)uridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C12H18N2O7
- MW
- 302.28
- Purity
- >=98%
2'-O-(2-Methoxyethyl)uridine (2'-O-MOE-U) is uridine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64034 is identified by CAS 223777-15-9, molecular formula C12H18N2O7, molecular weight 302.28, and PubChem CID 10881175.
In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64034 provides the uridine 2'-O-MOE nucleoside identity for related antisense-oligonucleotide research.
Synonyms
2'-O-(2-Methoxyethyl)uridine; 2'-O-MOE-U; 2'-MOE-U
Identity and specifications
| Catalog No. | CH64034 |
| CAS No. | 223777-15-9 |
| Molecular Formula | C12H18N2O7 |
| Molecular Weight | 302.28 |
| PubChem CID | 10881175 |
| InChIKey | XTXNROBDOKPICP-QCNRFFRDSA-N |
| Purity | >=98% |
Storage conditions
0-10 C
Technical attributes
- Nucleobase
- Uracil
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Nucleoside class
- MOE-modified pyrimidine ribonucleoside
- Packaging
- 1 g; Custom packaging on request
- Physical form
- Solid; white to light yellow powder to crystal
Application context
- MOE gapmer antisense research: CH64034 is relevant to gapmer antisense studies involving 2'-O-MOE uridine residues.
- Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
- 2'-O-MOE nucleoside reference: CH64034 provides the 2'-O-(2-methoxyethyl)uridine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 10881175
PubChem · CID 10881175
Frequently Asked Questions
How is 2'-O-MOE-uridine different from 2'-O-methyluridine?
Both are 2'-O-alkyl modifications, but MOE is a larger 2-methoxyethyl group versus a single methyl in 2'-O-methyl. 2'-O-methyluridine is cataloged separately.
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