7-Deaza-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H14N4O3
- MW
- 250.25
- Purity
- >98%
7-Deaza-2'-deoxyadenosine, also called 2'-deoxytubercidin (c7dA), is 2'-deoxyadenosine in which the purine N7 nitrogen is replaced by carbon, giving a pyrrolo[2,3-d]pyrimidine base. CH64045 is identified by CAS 60129-59-1, molecular formula C11H14N4O3, molecular weight 250.25, and PubChem CID 3006222.
The cited oligonucleotide literature discusses 7-deaza-dA analogs in base-pairing, metal-mediated base-pair, and duplex-stability studies where the N7 position is being examined. CH64045 provides the 7-deaza-2'-deoxyadenosine identity for related base-analog research.
Synonyms
7-Deaza-2'-deoxyadenosine; 2'-deoxytubercidin; c7dA; 7-deaza-dA
Identity and specifications
| Catalog No. | CH64045 |
| CAS No. | 60129-59-1 |
| Molecular Formula | C11H14N4O3 |
| Molecular Weight | 250.25 |
| PubChem CID | 3006222 |
| InChIKey | NIJSNUNKSPLDTO-DJLDLDEBSA-N |
| Purity | >98% |
Storage conditions
2-8 C; keep dark and dry
Technical attributes
- Nucleobase analog
- 7-Deazaadenine
- Sugar
- 2'-Deoxyribose
- Base modification
- 7-Deaza (N7 replaced by carbon)
- Research role
- Modified-oligonucleotide building-block reference
- Packaging
- 500 mg; 1 g; 10 g; 25 g; 50 g; 100 g; Custom packaging on request
- Physical form
- White to off-white powder
Application context
- 7-Deazapurine oligonucleotide research: CH64045 is relevant to base-pairing, metal-mediated base-pair, and duplex-stability studies involving the N7→C base modification.
- N7-position interaction studies: the 7-deaza base helps compare DNA systems where Hoogsteen or metal-binding behavior at the purine N7 position is being evaluated.
- Base-analog reference: CH64045 provides the 7-deaza-2'-deoxyadenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 3006222
PubChem · CID 3006222
Frequently Asked Questions
What is different about 7-deaza-2'-deoxyadenosine?
The purine N7 nitrogen is replaced by carbon, forming a 7-deazapurine / pyrrolo[2,3-d]pyrimidine base. This removes the N7 site considered in Hoogsteen and metal-binding studies.
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