7-Deaza-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H14N4O4
- MW
- 266.25
- Purity
- >=98.0%
7-Deaza-2'-deoxyguanosine (c7dG) is 2'-deoxyguanosine in which the purine N7 nitrogen is replaced by carbon, giving a pyrrolo[2,3-d]pyrimidine base. CH64046 is identified by CAS 86392-75-8, molecular formula C11H14N4O4, molecular weight 266.25, and PubChem CID 135411006.
The cited oligonucleotide literature discusses 7-deaza-dG analogs in base-pairing, duplex-stability, and sequencing band-compression studies where the purine N7 position is being evaluated.
Synonyms
7-Deaza-2'-deoxyguanosine; c7dG; 7-deaza-dG
Identity and specifications
| Catalog No. | CH64046 |
| CAS No. | 86392-75-8 |
| Molecular Formula | C11H14N4O4 |
| Molecular Weight | 266.25 |
| PubChem CID | 135411006 |
| InChIKey | PFCLMNDDPTZJHQ-XLPZGREQSA-N |
| Purity | >=98.0% |
Storage conditions
2-8 C; keep dark and dry
Technical attributes
- Nucleobase analog
- 7-Deazaguanine
- Sugar
- 2'-Deoxyribose
- Base modification
- 7-Deaza (N7 replaced by carbon)
- Research role
- Modified-oligonucleotide building-block reference
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; Custom packaging on request
- Physical form
- White to off-white powder
Application context
- 7-Deazapurine oligonucleotide research: CH64046 is relevant to base-pairing, duplex-stability, and sequencing band-compression studies involving the N7→C base modification.
- N7-position interaction studies: the 7-deaza base supports comparison of DNA systems where Hoogsteen contacts or metal-binding behavior at the purine N7 position is being evaluated.
- Base-analog reference: CH64046 provides the 7-deaza-2'-deoxyguanosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135411006
PubChem · CID 135411006
Frequently Asked Questions
What is different about 7-deaza-2'-deoxyguanosine?
The purine N7 nitrogen is replaced by carbon, giving a 7-deazapurine base. This allows comparison of systems where the purine N7 position is relevant to Hoogsteen pairing, metal binding, or sequencing band compression.
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