7-Deaza-7-Iodo-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H13IN4O3
- MW
- 376.15
- Purity
- >98.0% (HPLC)
7-Deaza-7-Iodo-2'-deoxyadenosine is 7-deaza-2'-deoxyadenosine carrying an iodine at the C7 position of the pyrrolo[2,3-d]pyrimidine base. CH64048 is identified by CAS 166247-63-8, molecular formula C11H13IN4O3, molecular weight 376.15, PubChem CID 15289165, and InChIKey LIIIRHQRQZIIRT-XLPZGREQSA-N.
In the cited 7-deazapurine literature, the C7-halogen position is discussed as a functionalization point for palladium cross-coupling reactions such as Sonogashira or Suzuki coupling. CH64048 provides the 7-deaza-7-iodo-dA identity for C7-functionalized oligonucleotide research.
Synonyms
7-Deaza-7-iodo-2'-deoxyadenosine; 7-iodo-c7dA
Identity and specifications
| Catalog No. | CH64048 |
| CAS No. | 166247-63-8 |
| Molecular Formula | C11H13IN4O3 |
| Molecular Weight | 376.15 |
| PubChem CID | 15289165 |
| InChIKey | LIIIRHQRQZIIRT-XLPZGREQSA-N |
| Purity | >98.0% (HPLC) |
Storage conditions
Room temperature; recommended <15 C, cool and dark, under inert gas; air sensitive
Technical attributes
- Nucleobase analog
- 7-Deazaadenine
- Sugar
- 2'-Deoxyribose
- Base modification
- 7-Deaza
- C7 substituent
- Iodo cross-coupling handle
- Packaging
- 200 mg; 500 mg; Custom packaging on request
- Physical form
- White to light yellow powder to crystal; solid at 20 C
Application context
- C7 cross-coupling research: the C7-iodine on the 7-deazapurine base is relevant to Sonogashira/Suzuki-style functionalization studies for C7-modified oligonucleotides.
- Modified-DNA studies: CH64048 combines the N7-removed 7-deazapurine scaffold with a C7 halogen position for base-analog research.
- Base-analog reference: CH64048 provides the 7-deaza-7-iodo-2'-deoxyadenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 15289165
PubChem · CID 15289165
Frequently Asked Questions
How is this different from 7-deaza-2'-deoxyadenosine?
It is 7-deaza-2'-deoxyadenosine with an added iodine at C7. The plain 7-deaza-dA is listed separately by CHEMOS.
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