7-TFA-ap-7-Deaza-2',3'-dideoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C16H16F3N5O4
- MW
- 399.32
- Purity
- >=98%
7-TFA-ap-7-Deaza-2',3'-dideoxyguanosine is a 2',3'-dideoxy 7-deazaguanosine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C7 position. CH64049 is identified by CAS 114748-68-4, molecular formula C16H16F3N5O4, molecular weight 399.32, PubChem CID 135577907, and InChIKey GMTOEMNRUPBIFY-VHSXEESVSA-N.
The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker, while the 2',3'-dideoxy sugar defines the chain-terminating nucleoside identity. The cited literature discusses amine-linker nucleosides and 7-deazapurine C7 functionalization in fluorescent labeling and DNA-sequencing research.
Synonyms
7-(3-trifluoroacetamidoprop-1-ynyl)-7-deaza-2',3'-dideoxyguanosine; 7-TFA-ap-c7-ddG
Identity and specifications
| Catalog No. | CH64049 |
| CAS No. | 114748-68-4 |
| Molecular Formula | C16H16F3N5O4 |
| Molecular Weight | 399.32 |
| PubChem CID | 135577907 |
| InChIKey | GMTOEMNRUPBIFY-VHSXEESVSA-N |
| Purity | >=98% |
Storage conditions
-20 C as powder; -80 C in solvent
Technical attributes
- Nucleobase analog
- 7-Deazaguanine
- Sugar
- 2',3'-Dideoxyribose
- C7 linker
- 3-Aminoprop-1-ynyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 100 mg; 500 mg; Custom packaging on request
- Physical form
- Powder
- Stability
- 3 years as powder; 1 year in solvent
Application context
- Labeled terminator research: CH64049 combines a 2',3'-dideoxy nucleoside identity with a C7 aminopropynyl linker for DNA-sequencing and labeling studies.
- Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64049 provides the 7-TFA-ap-7-deaza-2',3'-dideoxyguanosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135577907
PubChem · CID 135577907
Frequently Asked Questions
What do 'TFA' and 'ap' mean in the name?
'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at C7, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.
Why is it a chain terminator?
It is a 2',3'-dideoxynucleoside, which is the sugar pattern associated with chain-terminator designs in DNA-sequencing research. CH64049 also carries a protected C7 amino-linker.
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