7-TFA-ap-7-Deaza-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C16H16F3N5O4
- MW
- 399.32
- Purity
- >=98%
7-TFA-ap-7-Deaza-2'-deoxyadenosine is a 2'-deoxy 7-deazaadenosine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C7 position. CH64052 is identified by CAS 178420-75-2, molecular formula C16H16F3N5O4, molecular weight 399.32, PubChem CID 15450746, and InChIKey SVVZRCQYSUXVDB-HBNTYKKESA-N.
The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker. Because the sugar is 2'-deoxy rather than 2',3'-dideoxy, CH64052 is positioned for internal oligonucleotide labeling research rather than chain-terminator designs.
Synonyms
7-(3-trifluoroacetamidoprop-1-ynyl)-7-deaza-2'-deoxyadenosine; 7-TFA-ap-c7-dA
Identity and specifications
| Catalog No. | CH64052 |
| CAS No. | 178420-75-2 |
| Molecular Formula | C16H16F3N5O4 |
| Molecular Weight | 399.32 |
| PubChem CID | 15450746 |
| InChIKey | SVVZRCQYSUXVDB-HBNTYKKESA-N |
| Purity | >=98% |
Storage conditions
4 C, sealed, away from moisture and light
Technical attributes
- Nucleobase analog
- 7-Deazaadenine
- Sugar
- 2'-Deoxyribose
- C7 linker
- 3-Aminoprop-1-ynyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; Custom packaging on request
- Physical form
- Off-white to brown solid powder
- Stability
- 3 years at -20 C or 2 years at 4 C as powder; 6 months at -80 C or 1 month at -20 C in solvent
Application context
- Internal-labeling research: CH64052 combines a 2'-deoxy nucleoside identity with a C7 aminopropynyl linker for oligonucleotide labeling studies.
- Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64052 provides the 7-TFA-ap-7-deaza-2'-deoxyadenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 15450746
PubChem · CID 15450746
Frequently Asked Questions
Is this a chain terminator?
No. It is a 2'-deoxy nucleoside, not a 2',3'-dideoxy nucleoside. The dideoxy version is the chain-terminator design and is listed separately.
What do 'TFA' and 'ap' mean?
'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at C7, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.
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