5-TFA-ap-2'-deoxyuridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C14H14F3N3O6
- MW
- 377.27
- Purity
- 98%
5-TFA-ap-2'-deoxyuridine is 2'-deoxyuridine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C5 position of uracil. CH64053 is identified by CAS 115899-40-6, molecular formula C14H14F3N3O6, molecular weight 377.27, PubChem CID 10894132, and InChIKey HCKMZBZCHQQZRJ-IVZWLZJFSA-N.
The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker. The cited labeling literature discusses amine-linker nucleosides as motifs for covalent fluorophore attachment in nucleoside and oligonucleotide labeling research.
Synonyms
5-(3-trifluoroacetamidoprop-1-ynyl)-2'-deoxyuridine; 5-TFA-ap-dU
Identity and specifications
| Catalog No. | CH64053 |
| CAS No. | 115899-40-6 |
| Molecular Formula | C14H14F3N3O6 |
| Molecular Weight | 377.27 |
| PubChem CID | 10894132 |
| InChIKey | HCKMZBZCHQQZRJ-IVZWLZJFSA-N |
| Purity | 98% |
Storage conditions
Room temperature
Technical attributes
- Nucleobase
- Uracil
- Sugar
- 2'-Deoxyribose
- C5 linker
- 3-Aminoprop-1-ynyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 100 mg; 250 mg; 1 g; Custom packaging on request
Application context
- Internal-labeling research: CH64053 combines a 2'-deoxyuridine identity with a C5 aminopropynyl linker for oligonucleotide labeling studies.
- Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64053 provides the 5-TFA-ap-2'-deoxyuridine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 10894132
PubChem · CID 10894132
Frequently Asked Questions
What do 'TFA' and 'ap' mean in the name?
'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at the C5 position of uracil, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.
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