5-TFA-ap-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C14H15F3N4O5
- MW
- 376.29
- Purity
- 97%
5-TFA-ap-2'-deoxycytidine is 2'-deoxycytidine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C5 position of cytosine. CH64054 is identified by CAS 115899-38-2, molecular formula C14H15F3N4O5, molecular weight 376.29, PubChem CID 14768553, and InChIKey OKLUSVKQOCPUNW-IVZWLZJFSA-N.
The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker. The cited labeling literature discusses amine-linker nucleosides as motifs for covalent fluorophore attachment in nucleoside and oligonucleotide labeling research.
Synonyms
5-(3-trifluoroacetamidoprop-1-ynyl)-2'-deoxycytidine; 5-TFA-ap-dC
Identity and specifications
| Catalog No. | CH64054 |
| CAS No. | 115899-38-2 |
| Molecular Formula | C14H15F3N4O5 |
| Molecular Weight | 376.29 |
| PubChem CID | 14768553 |
| InChIKey | OKLUSVKQOCPUNW-IVZWLZJFSA-N |
| Purity | 97% |
Storage conditions
2-8 C, protect from light
Technical attributes
- Nucleobase
- Cytosine
- Sugar
- 2'-Deoxyribose
- C5 linker
- 3-Aminoprop-1-ynyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; 25 uL sample solution; Custom packaging on request
- Solution concentration
- 10 mM supplied sample solution
- Physical form
- A solid
Application context
- Internal-labeling research: CH64054 combines a 2'-deoxycytidine identity with a C5 aminopropynyl linker for oligonucleotide labeling studies.
- Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64054 provides the 5-TFA-ap-2'-deoxycytidine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 14768553
PubChem · CID 14768553
Frequently Asked Questions
What do 'TFA' and 'ap' mean in the name?
'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at the C5 position of cytosine, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.
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