5-TFA-aha-2'-deoxyuridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C20H27F3N4O7
- MW
- 492.4
- Purity
- >98.00%
5-TFA-aha-2'-deoxyuridine is 2'-deoxyuridine carrying a longer amino-linker (the "aha" arm) at the C5 position of uracil, with the linker's terminal amine protected as a trifluoroacetamide (TFA). CH64055 is identified by CAS 252337-58-9, molecular formula C20H27F3N4O7, molecular weight 492.4, PubChem CID 15484914, and InChIKey CSMRZKBUOFUSRQ-JHCHYBNPSA-N.
Compared with the shorter C5 aminopropynyl linker in 5-TFA-ap-2'-deoxyuridine, the larger formula and PubChem structure indicate a longer spacer arm. The cited labeling literature discusses amine-linker nucleosides as motifs for covalent fluorophore attachment in nucleoside and oligonucleotide labeling research.
Synonyms
5-TFA-aha-dU; 5-[TFA-protected aminohexanoyl-type amino-linker]-2'-deoxyuridine
Identity and specifications
| Catalog No. | CH64055 |
| CAS No. | 252337-58-9 |
| Molecular Formula | C20H27F3N4O7 |
| Molecular Weight | 492.4 |
| PubChem CID | 15484914 |
| InChIKey | CSMRZKBUOFUSRQ-JHCHYBNPSA-N |
| Purity | >98.00% |
Storage conditions
2-8 C, away from moisture, sealed storage
Technical attributes
- Nucleobase
- Uracil
- Sugar
- 2'-Deoxyribose
- C5 linker
- Aminohexanoyl-type long spacer
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 25 mg; 100 mg; Custom packaging on request
Application context
- Long-spacer labeling research: CH64055 combines a 2'-deoxyuridine identity with a C5 TFA-protected "aha" amino-linker for oligonucleotide labeling and linker-spacing studies.
- Amine-linker labeling studies: the TFA-protected terminal amine represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64055 provides the 5-TFA-aha-2'-deoxyuridine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 15484914
PubChem · CID 15484914
Frequently Asked Questions
How is the 'aha' linker different from the 'ap' linker?
The 'aha' amino-linker is longer than the propynyl 'ap' linker, giving a larger spacer between the base and the terminal amine. The shorter 5-TFA-ap-2'-deoxyuridine is cataloged separately.
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