5-TFA-aa-Uridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C14H16F3N3O7
- MW
- 395.29
- Purity
- >98.00%
5-TFA-aa-Uridine is uridine carrying an aminoallyl amino-linker at the C5 position of uracil, with the linker's terminal amine protected as a trifluoroacetamide (TFA). CH64057 is identified by CAS 869222-68-4, molecular formula C14H16F3N3O7, molecular weight 395.29, PubChem CID 71463691, and InChIKey DMXZSDJKAIYXMV-TVIFIVJDSA-N.
The aminoallyl arm provides a protected amine-linker motif on a ribonucleoside. The cited labeling literature discusses amine-linker nucleosides in covalent fluorophore attachment and indirect labeling research for nucleic acids.
Synonyms
5-(trifluoroacetamidoallyl)uridine; 5-TFA-aa-U; TFA-aminoallyl-uridine
Identity and specifications
| Catalog No. | CH64057 |
| CAS No. | 869222-68-4 |
| Molecular Formula | C14H16F3N3O7 |
| Molecular Weight | 395.29 |
| PubChem CID | 71463691 |
| InChIKey | DMXZSDJKAIYXMV-TVIFIVJDSA-N |
| Purity | >98.00% |
Storage conditions
2-8 C, away from moisture
Technical attributes
- Nucleobase
- Uracil
- Sugar
- D-Ribose
- C5 linker
- Aminoallyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 50 mg; 100 mg; 250 mg; 1 g; Custom packaging on request
Application context
- Aminoallyl labeling research: CH64057 combines a uridine identity with a C5 TFA-protected aminoallyl linker for indirect nucleic-acid labeling studies.
- Amine-linker labeling studies: the TFA-protected aminoallyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64057 provides the 5-TFA-aa-uridine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 71463691
PubChem · CID 71463691
Frequently Asked Questions
What does 'aa' (aminoallyl) mean here?
'aa' is the aminoallyl linker, a 3-aminoprop-1-enyl arm at the C5 position. Its terminal amine is protected as a trifluoroacetamide (TFA).
Is this the RNA or DNA nucleoside?
It is a uridine (ribonucleoside). The 2'-deoxy aminoallyl versions (dU, dC) are cataloged separately.
Similar Products
Need Help with Material Selection?
CHEMOS can review product fit, target structure, route questions, analytical expectations, and project-specific supply needs.