8-Bromo-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H12BrN5O4
- MW
- 346.14
- Purity
- >98% (HPLC)
8-Bromo-2'-deoxyguanosine is 2'-deoxyguanosine bearing a bromine at the C8 position of guanine. CH64065 is identified by CAS 13389-03-2, molecular formula C10H12BrN5O4, molecular weight 346.14, PubChem CID 135437126, and InChIKey MKDXZFVCXWXGBQ-VPENINKCSA-N.
The cited literature discusses 8-substituted purine nucleosides and nucleotides in relation to syn/anti glycosidic conformation, including 8-bromoguanine nucleosides. CH64065 provides the 8-bromo-2'-deoxyguanosine identity for modified-DNA, base-analog, and C8-functionalization research contexts.
Synonyms
8-Bromo-2'-deoxyguanosine; 8-Br-dG
Identity and specifications
| Catalog No. | CH64065 |
| CAS No. | 13389-03-2 |
| Molecular Formula | C10H12BrN5O4 |
| Molecular Weight | 346.14 |
| PubChem CID | 135437126 |
| InChIKey | MKDXZFVCXWXGBQ-VPENINKCSA-N |
| Purity | >98% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Guanine
- Sugar
- 2'-Deoxyribose
- Base substituent
- 8-Bromo
- Conformational context
- 8-Substituted purine; syn-favoring
- Packaging
- 100 mg; 1 g; 10 g; 25 g; 50 g; 10 umol (~3.5 mg); 5 x 10 umol; Custom packaging on request
- Physical form
- solid
- Stability
- Powder: 2 years; in solution: 6 months at -20 C or 1 year at -80 C
Application context
- syn-Conformation research: the cited literature discusses 8-substituted purines, including 8-bromoguanine nucleosides, as systems with defined syn/anti glycosidic conformational behavior.
- C8-functionalization studies: the C8 bromine marks a chemically addressable position on the guanine base for modified-DNA and nucleoside research.
- Base-analog reference: CH64065 provides the 8-bromo-2'-deoxyguanosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135437126
PubChem · CID 135437126
Frequently Asked Questions
How does it differ from 2'-deoxyguanosine?
It carries a bromine at the C8 position of guanine, whereas 2'-deoxyguanosine is unsubstituted. 2'-deoxyguanosine is cataloged separately.
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