8-Bromo-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H12BrN5O3
- MW
- 330.14
- Purity
- >98% (HPLC)
8-Bromo-2'-deoxyadenosine is 2'-deoxyadenosine bearing a bromine at the C8 position of adenine. CH64067 is identified by CAS 14985-44-5, molecular formula C10H12BrN5O3, molecular weight 330.14, PubChem CID 96547, and InChIKey NJBIVXMQFIQOGE-KVQBGUIXSA-N.
The cited literature discusses 8-substituted purine nucleosides and nucleotides in relation to syn/anti glycosidic conformation. CH64067 provides the 8-bromo-2'-deoxyadenosine identity for modified-DNA, base-analog, and C8-functionalization research contexts.
Synonyms
8-Bromo-2'-deoxyadenosine; 8-Br-dA
Identity and specifications
| Catalog No. | CH64067 |
| CAS No. | 14985-44-5 |
| Molecular Formula | C10H12BrN5O3 |
| Molecular Weight | 330.14 |
| PubChem CID | 96547 |
| InChIKey | NJBIVXMQFIQOGE-KVQBGUIXSA-N |
| Purity | >98% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Adenine
- Sugar
- 2'-Deoxyribose
- Base substituent
- 8-Bromo
- Conformational context
- 8-Substituted purine; syn-favoring
- Packaging
- 100 mg; 500 mg; 1 g; 5 g; 10 umol (~3.3 mg); 5 x 10 umol; Custom packaging on request
Application context
- syn-Conformation research: the cited literature discusses 8-substituted purines as systems with defined syn/anti glycosidic conformational behavior.
- C8-functionalization studies: the C8 bromine marks a chemically addressable position on the adenine base for modified-DNA and nucleoside research.
- Base-analog reference: CH64067 provides the 8-bromo-2'-deoxyadenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 96547
PubChem · CID 96547
Frequently Asked Questions
How does it differ from 2'-deoxyadenosine?
It carries a bromine at the C8 position of adenine, whereas 2'-deoxyadenosine is unsubstituted. 2'-deoxyadenosine is cataloged separately.
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