8-Chloroadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H12ClN5O4
- MW
- 301.69
- Purity
- >98% (HPLC)
8-Chloroadenosine is adenosine bearing a chlorine at the C8 position of adenine. CH64068 is identified by CAS 34408-14-5, molecular formula C10H12ClN5O4, molecular weight 301.69, PubChem CID 147569, and InChIKey MHDPPLULTMGBSI-UUOKFMHZSA-N.
The cited literature discusses 8-substituted purine nucleosides and nucleotides in relation to syn/anti glycosidic conformation, including 8-chloro derivatives. CH64068 provides the 8-chloroadenosine identity for conformational, base-analog, and C8-functionalization research contexts.
Synonyms
8-Chloroadenosine; 8-Cl-adenosine; 8-Cl-Ado
Identity and specifications
| Catalog No. | CH64068 |
| CAS No. | 34408-14-5 |
| Molecular Formula | C10H12ClN5O4 |
| Molecular Weight | 301.69 |
| PubChem CID | 147569 |
| InChIKey | MHDPPLULTMGBSI-UUOKFMHZSA-N |
| Purity | >98% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Adenine
- Sugar
- D-Ribose
- Base substituent
- 8-Chloro
- Conformational context
- 8-Substituted purine; syn-favoring
- Packaging
- 10 umol (~3 mg); 5 x 10 umol; Custom packaging on request
- Physical form
- solid
- Stability
- >=4 years
Application context
- syn-Conformation research: the cited literature discusses 8-substituted purines, including 8-chloro derivatives, as systems with defined syn/anti glycosidic conformational behavior.
- C8-functionalization studies: the C8 chlorine marks a chemically addressable position on the adenine base for nucleoside research.
- Base-analog reference: CH64068 provides the 8-chloroadenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 147569
PubChem · CID 147569
Frequently Asked Questions
How does it differ from adenosine?
It carries a chlorine at the C8 position of adenine, whereas adenosine is unsubstituted. Adenosine is cataloged separately.
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