8-Thioguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H13N5O5S
- MW
- 315.31
- Purity
- 98.0%
8-Thioguanosine (8-mercaptoguanosine) is guanosine bearing a thiol/thioxo group at the C8 position of guanine. CH64069 is identified by CAS 26001-38-7, molecular formula C10H13N5O5S, molecular weight 315.31, PubChem CID 135457302, and InChIKey KZELNMSPWPFAEB-UMMCILCDSA-N.
The cited literature discusses bulky C8 substitution in purine nucleosides and nucleotides in relation to syn glycosidic conformation. CH64069 provides the 8-thioguanosine identity for base-analog, bulky-C8 purine, and nucleoside chemistry research.
Synonyms
8-Thioguanosine; 8-mercaptoguanosine; 8-MGuo
Identity and specifications
| Catalog No. | CH64069 |
| CAS No. | 26001-38-7 |
| Molecular Formula | C10H13N5O5S |
| Molecular Weight | 315.31 |
| PubChem CID | 135457302 |
| InChIKey | KZELNMSPWPFAEB-UMMCILCDSA-N |
| Purity | 98.0% |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Guanine
- Sugar
- D-Ribose
- Base modification
- 8-Thio (8-mercapto)
- Conformational context
- 8-Substituted purine; syn-favoring
- Packaging
- 50 mg; 100 mg; 250 mg; 500 mg; Custom packaging on request
- Physical form
- white crystalline solid
- Stability
- In solution: 6 months at -80 C or 1 month at -20 C
Application context
- 8-Substituted purine research: CH64069 is a C8-thio guanosine analog for bulky-C8 purine and syn/anti glycosidic conformation research contexts.
- Base-analog reference: CH64069 provides the 8-thioguanosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135457302
PubChem · CID 135457302
Frequently Asked Questions
What kind of modification does 8-thioguanosine carry?
It has a thiol/thioxo (mercapto) group at the C8 position of guanine, making it an 8-substituted bulky-C8 purine nucleoside.
How does it differ from guanosine?
It carries a C8-thio group, whereas guanosine is unsubstituted. Guanosine is cataloged separately.
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