8-Thioadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H13N5O4S
- MW
- 299.31
- Purity
- >=97%
8-Thioadenosine (8-mercaptoadenosine) is adenosine bearing a thiol/thioxo group at the C8 position of adenine. CH64070 is identified by CAS 3001-45-4, molecular formula C10H13N5O4S, molecular weight 299.31, PubChem CID 10615718, and InChIKey QILZVYQRHGBEAR-UUOKFMHZSA-N.
The cited literature discusses bulky C8 substitution in purine nucleosides and nucleotides in relation to syn glycosidic conformation. CH64070 provides the 8-thioadenosine identity for base-analog, bulky-C8 purine, and nucleoside chemistry research.
Synonyms
8-Thioadenosine; 8-mercaptoadenosine
Identity and specifications
| Catalog No. | CH64070 |
| CAS No. | 3001-45-4 |
| Molecular Formula | C10H13N5O4S |
| Molecular Weight | 299.31 |
| PubChem CID | 10615718 |
| InChIKey | QILZVYQRHGBEAR-UUOKFMHZSA-N |
| Purity | >=97% |
Storage conditions
sealed and dry at 2-8 C
Technical attributes
- Nucleobase
- Adenine
- Sugar
- D-Ribose
- Base modification
- 8-Thio (8-mercapto)
- Conformational context
- 8-Substituted purine; syn-favoring
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; 10 g; Custom packaging on request
- Stability
- Powder: 3 years; in solution: 1 year
Application context
- 8-Substituted purine research: CH64070 is a C8-thio adenosine analog for bulky-C8 purine and syn/anti glycosidic conformation research contexts.
- Base-analog reference: CH64070 provides the 8-thioadenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 10615718
PubChem · CID 10615718
Frequently Asked Questions
What kind of modification does 8-thioadenosine carry?
It has a thiol/thioxo (mercapto) group at the C8 position of adenine, making it an 8-substituted bulky-C8 purine nucleoside.
How does it differ from adenosine?
It carries a C8-thio group, whereas adenosine is unsubstituted. Adenosine is cataloged separately.
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