8-Hydroxy-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H13N5O5
- MW
- 283.24
- Purity
- >=98%
8-Hydroxy-2'-deoxyguanosine (8-oxo-dG) is the C8-oxidized form of 2'-deoxyguanosine. CH64071 is identified by CAS 88847-89-6, molecular formula C10H13N5O5, molecular weight 283.24, PubChem CID 135440064, and InChIKey HCAJQHYUCKICQH-VPENINKCSA-N.
The cited oxidative-stress literature discusses 8-hydroxy-2'-deoxyguanosine as a form of oxidative DNA damage and a marker of cellular oxidative stress. CH64071 provides the 8-oxo-dG identity for oxidative DNA damage, oxidized nucleoside, and nucleoside chemistry research.
Synonyms
8-Hydroxy-2'-deoxyguanosine; 8-oxo-dG; 8-oxo-2'-deoxyguanosine; 8-OHdG
Identity and specifications
| Catalog No. | CH64071 |
| CAS No. | 88847-89-6 |
| Molecular Formula | C10H13N5O5 |
| Molecular Weight | 283.24 |
| PubChem CID | 135440064 |
| InChIKey | HCAJQHYUCKICQH-VPENINKCSA-N |
| Purity | >=98% |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Oxidized guanine
- Sugar
- 2'-Deoxyribose
- Base modification
- 8-Hydroxy / 8-oxo
- Research role
- Oxidative-DNA-damage nucleoside reference
- Grade
- for Biochemistry
- Packaging
- 5 mg; 5 umol (~1.5 mg); 5 x 5 umol; Custom packaging on request
- Physical form
- crystalline solid
- Stability
- >=4 years
Application context
- Oxidative-DNA-damage marker research: the cited literature discusses 8-oxo-dG as a form of oxidative DNA damage and a marker of cellular oxidative stress.
- Oxidized nucleoside reference: CH64071 provides the 8-hydroxy-2'-deoxyguanosine identity for oxidized nucleoside and nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135440064
PubChem · CID 135440064
Frequently Asked Questions
How does it differ from 2'-deoxyguanosine?
It is the C8-oxidized (8-oxo/8-hydroxy) form of 2'-deoxyguanosine, whereas 2'-deoxyguanosine is unmodified. 2'-deoxyguanosine is cataloged separately.
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