N6-Benzoyl-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C17H17N5O4
- MW
- 355.35
- Purity
- >=98.0% (HPLC)
N6-Benzoyl-2'-deoxyadenosine (dABz) is 2'-deoxyadenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64072 is identified by CAS 4546-72-9, molecular formula C17H17N5O4, molecular weight 355.35, PubChem CID 107558, and InChIKey PIXHJAPVPCVZSV-YNEHKIRRSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64072 provides the N6-benzoyl-protected 2'-deoxyadenosine identity for DNA building-block and nucleoside chemistry research.
Synonyms
N6-Benzoyl-2'-deoxyadenosine; N6-Bz-dA; dABz
Identity and specifications
| Catalog No. | CH64072 |
| CAS No. | 4546-72-9 |
| Molecular Formula | C17H17N5O4 |
| Molecular Weight | 355.35 |
| PubChem CID | 107558 |
| InChIKey | PIXHJAPVPCVZSV-YNEHKIRRSA-N |
| Purity | >=98.0% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Adenine
- Sugar
- 2'-Deoxyribose
- Base protection
- N6-Benzoyl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- Custom packaging on request
- Physical form
- crystalline solid
- Stability
- >=4 years
Application context
- Base-protected DNA building block: the N6-benzoyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Adenine (dA) monomer precursor context: CH64072 is the base-protected 2'-deoxyadenosine identity relevant to adenine building-block preparation.
- Nucleoside chemistry reference: CH64072 provides the N6-benzoyl-2'-deoxyadenosine (dABz) identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 107558
PubChem · CID 107558
Frequently Asked Questions
Why is the N6-amine of this deoxyadenosine benzoylated?
In oligonucleotide synthesis the reactive exocyclic amine of adenine is masked with a protecting group such as benzoyl to prevent side reactions; the benzoyl group is later removed during deprotection.
How does it differ from 2'-deoxyadenosine?
It carries a benzoyl group on the adenine N6-amine, whereas 2'-deoxyadenosine is unprotected. 2'-deoxyadenosine is cataloged separately.
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