N4-Benzoyl-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C16H17N3O5
- MW
- 331.32
- Purity
- >98.0% (HPLC)
N4-Benzoyl-2'-deoxycytidine (dCBz) is 2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64073 is identified by CAS 4836-13-9, molecular formula C16H17N3O5, molecular weight 331.32, PubChem CID 9797617, and InChIKey MPSJHJFNKMUKCN-OUCADQQQSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64073 provides the N4-benzoyl-protected 2'-deoxycytidine identity for DNA building-block and nucleoside chemistry research.
Synonyms
N4-Benzoyl-2'-deoxycytidine; N4-Bz-dC; dCBz
Identity and specifications
| Catalog No. | CH64073 |
| CAS No. | 4836-13-9 |
| Molecular Formula | C16H17N3O5 |
| Molecular Weight | 331.32 |
| PubChem CID | 9797617 |
| InChIKey | MPSJHJFNKMUKCN-OUCADQQQSA-N |
| Purity | >98.0% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Cytosine
- Sugar
- 2'-Deoxyribose
- Base protection
- N4-Benzoyl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 100 mg; 1 g; Custom packaging on request
- Physical form
- solid
- Stability
- >=4 years
Application context
- Base-protected DNA building block: the N4-benzoyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Cytosine (dC) monomer precursor context: CH64073 is the base-protected 2'-deoxycytidine identity relevant to cytosine building-block preparation.
- Nucleoside chemistry reference: CH64073 provides the N4-benzoyl-2'-deoxycytidine (dCBz) identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 9797617
PubChem · CID 9797617
Frequently Asked Questions
Why is the N4-amine of this deoxycytidine benzoylated?
In oligonucleotide synthesis the reactive exocyclic amine of cytosine is masked with a protecting group such as benzoyl to prevent side reactions; the benzoyl group is later removed during deprotection.
How does it differ from 2'-deoxycytidine?
It carries a benzoyl group on the cytosine N4-amine, whereas 2'-deoxycytidine is unprotected. 2'-deoxycytidine is cataloged separately.
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