N2-Isobutyryl-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C14H19N5O5
- MW
- 337.33
- Purity
- >98.0% (HPLC)
N2-Isobutyryl-2'-deoxyguanosine (dGiBu) is 2'-deoxyguanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64074 is identified by CAS 68892-42-2, molecular formula C14H19N5O5, molecular weight 337.33, PubChem CID 135407017, and InChIKey SIDXEQFMTMICKG-DJLDLDEBSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64074 provides the N2-isobutyryl-protected 2'-deoxyguanosine identity for DNA building-block and nucleoside chemistry research.
Synonyms
N2-Isobutyryl-2'-deoxyguanosine; N2-ibu-dG; dGiBu
Identity and specifications
| Catalog No. | CH64074 |
| CAS No. | 68892-42-2 |
| Molecular Formula | C14H19N5O5 |
| Molecular Weight | 337.33 |
| PubChem CID | 135407017 |
| InChIKey | SIDXEQFMTMICKG-DJLDLDEBSA-N |
| Purity | >98.0% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Guanine
- Sugar
- 2'-Deoxyribose
- Base protection
- N2-Isobutyryl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 100 mg; 1 g; Custom packaging on request
- Physical form
- solid
- Stability
- >=4 years
Application context
- Base-protected DNA building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Guanine (dG) monomer precursor context: CH64074 is the base-protected 2'-deoxyguanosine identity relevant to guanine building-block preparation.
- Nucleoside chemistry reference: CH64074 provides the N2-isobutyryl-2'-deoxyguanosine (dGiBu) identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135407017
PubChem · CID 135407017
Frequently Asked Questions
Why is the N2-amine of this deoxyguanosine protected with isobutyryl?
In oligonucleotide synthesis the reactive exocyclic amine of guanine is masked with a protecting group such as isobutyryl to prevent side reactions; the isobutyryl group is later removed during deprotection.
How does it differ from 2'-deoxyguanosine?
It carries an isobutyryl group on the guanine N2-amine, whereas 2'-deoxyguanosine is unprotected. 2'-deoxyguanosine is cataloged separately.
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