N4-Acetyl-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H15N3O5
- MW
- 269.25
- Purity
- >=99.0% (HPLC)
N4-Acetyl-2'-deoxycytidine (dCAc) is 2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with an acetyl group. CH64075 is identified by CAS 32909-05-0, molecular formula C11H15N3O5, molecular weight 269.25, PubChem CID 11346228, and InChIKey RWYFZABPLDFELM-QXFUBDJGSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64075 provides the N4-acetyl-protected 2'-deoxycytidine identity for DNA building-block and nucleoside chemistry research.
Synonyms
N4-Acetyl-2'-deoxycytidine; N4-Ac-dC; dCAc
Identity and specifications
| Catalog No. | CH64075 |
| CAS No. | 32909-05-0 |
| Molecular Formula | C11H15N3O5 |
| Molecular Weight | 269.25 |
| PubChem CID | 11346228 |
| InChIKey | RWYFZABPLDFELM-QXFUBDJGSA-N |
| Purity | >=99.0% (HPLC) |
Storage conditions
2-8 C; dark and dry
Technical attributes
- Nucleobase
- Cytosine
- Sugar
- 2'-Deoxyribose
- Base protection
- N4-Acetyl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 5 g; 10 g; 25 g; 100 g; 250 g; Custom packaging on request
- Physical form
- white off-white to faint-yellow powder
- Stability
- Powder: 3 years; in solution: 1 year
Application context
- Base-protected DNA building block: the N4-acetyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Cytosine (dC) monomer precursor context: CH64075 is the acetyl-protected 2'-deoxycytidine identity relevant to cytosine building-block preparation.
- Nucleoside chemistry reference: CH64075 provides the N4-acetyl-2'-deoxycytidine (dCAc) identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 11346228
PubChem · CID 11346228
Frequently Asked Questions
Why is the N4-amine of this deoxycytidine acetylated?
In oligonucleotide synthesis the reactive exocyclic amine of cytosine is masked with a protecting group such as acetyl to prevent side reactions; the acetyl group is later removed during deprotection.
How does it differ from N4-benzoyl-2'-deoxycytidine?
Both protect the cytosine N4-amine, but this one uses an acetyl group rather than benzoyl. N4-benzoyl-2'-deoxycytidine is cataloged separately.
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