N6-Acetyl-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C12H15N5O4
- MW
- 293.28
- Purity
- >=97% (HPLC)
N6-Acetyl-2'-deoxyadenosine (dAAc) is 2'-deoxyadenosine whose adenine exocyclic N6-amine is protected with an acetyl group. CH64076 is identified by CAS 1443367-96-1, molecular formula C12H15N5O4, molecular weight 293.28, PubChem CID 23275717, and InChIKey DKVIBEFOBOVION-UHFFFAOYSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64076 provides the N6-acetyl-protected 2'-deoxyadenosine identity for DNA building-block and nucleoside chemistry research.
Synonyms
N6-Acetyl-2'-deoxyadenosine; N6-Ac-dA; dAAc
Identity and specifications
| Catalog No. | CH64076 |
| CAS No. | 1443367-96-1 |
| Molecular Formula | C12H15N5O4 |
| Molecular Weight | 293.28 |
| PubChem CID | 23275717 |
| InChIKey | DKVIBEFOBOVION-UHFFFAOYSA-N |
| Purity | >=97% (HPLC) |
Storage conditions
Solid product: 2-8 C; user-prepared stock solution: -80 C or -20 C
Technical attributes
- Nucleobase
- Adenine
- Sugar
- 2'-Deoxyribose
- Base protection
- N6-Acetyl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 25 mg; 100 mg; 250 mg; 1 g; 10 g; Custom packaging on request
- Solution concentration
- 10 mM in 25 uL sample solution only
- Stability
- User-prepared stock solution: 6 months at -80 C; 1 month at -20 C
Application context
- Base-protected DNA building block: the N6-acetyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Adenine (dA) monomer precursor context: CH64076 is the acetyl-protected 2'-deoxyadenosine identity relevant to adenine building-block preparation.
- Nucleoside chemistry reference: CH64076 provides the N6-acetyl-2'-deoxyadenosine (dAAc) identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 23275717
PubChem · CID 23275717
Frequently Asked Questions
Why is the N6-amine of this deoxyadenosine acetylated?
In oligonucleotide synthesis the reactive exocyclic amine of adenine is masked with a protecting group such as acetyl to prevent side reactions; the acetyl group is later removed during deprotection.
How does it differ from N6-benzoyl-2'-deoxyadenosine?
Both protect the adenine N6-amine, but this one uses an acetyl group rather than benzoyl. N6-benzoyl-2'-deoxyadenosine is cataloged separately.
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