N2-(Dimethylaminomethylene)-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C13H18N6O4
- MW
- 322.32
- Purity
- >=98.0% (HPLC)
N2-(Dimethylaminomethylene)-2'-deoxyguanosine (dmf-dG) is 2'-deoxyguanosine whose guanine exocyclic N2-amine is protected with a dimethylformamidine (dmf) group. CH64078 is identified by CAS 17331-13-4, molecular formula C13H18N6O4, molecular weight 322.32, PubChem CID 135882612, and InChIKey ZXECVVVXPHBGGX-DJLDLDEBSA-N.
The cited oligonucleotide-synthesis literature discusses dimethylformamidine as a labile guanine base-protecting group and describes removal of base-protecting groups during deprotection. CH64078 provides the N2-dmf-protected 2'-deoxyguanosine identity for DNA building-block and nucleoside chemistry research.
Synonyms
N2-(Dimethylaminomethylene)-2'-deoxyguanosine; N2-dmf-dG; dG(dmf)
Identity and specifications
| Catalog No. | CH64078 |
| CAS No. | 17331-13-4 |
| Molecular Formula | C13H18N6O4 |
| Molecular Weight | 322.32 |
| PubChem CID | 135882612 |
| InChIKey | ZXECVVVXPHBGGX-DJLDLDEBSA-N |
| Purity | >=98.0% (HPLC) |
Storage conditions
+2 to +8 C
Technical attributes
- Nucleobase
- Guanine
- Sugar
- 2'-Deoxyribose
- Base protection
- N2-Dimethylaminomethylene (dmf)
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 1 g; 5 g; 10 g; 20 g; 25 g; 50 g; solid-plus-solvent kit: 1 mL reconstitution volume; Solid: 500 mg; supplied solution: 1 mL; Custom packaging on request
- Solution concentration
- 10 mM x 1 mL in DMSO supplied solution; 10 mM x 1 mL in DMSO solid-plus-solvent kit
- Water content
- <=2% KF
- Physical form
- white to off-white powder
- Stability
- User-prepared stock solution: 6 months at -80 C; 1 month at -20 C
Application context
- Base-protected DNA building block: the N2-dimethylformamidine group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Guanine (dG) monomer precursor context: CH64078 is the dmf-protected 2'-deoxyguanosine identity relevant to guanine building-block preparation.
- Nucleoside chemistry reference: CH64078 provides the N2-dmf-2'-deoxyguanosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135882612
PubChem · CID 135882612
Frequently Asked Questions
How does it differ from N2-isobutyryl-2'-deoxyguanosine?
Both protect the guanine N2-amine, but this one uses a dimethylformamidine (dmf) group rather than isobutyryl. N2-isobutyryl-2'-deoxyguanosine is cataloged separately.
Similar Products
Need Help with Material Selection?
CHEMOS can review product fit, target structure, route questions, analytical expectations, and project-specific supply needs.