N6-Benzoyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C17H17N5O5
- MW
- 371.35
- Purity
- >=98%
N6-Benzoyladenosine (rABz) is adenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64081 is identified by CAS 4546-55-8, molecular formula C17H17N5O5, molecular weight 371.35, PubChem CID 11728391, and InChIKey NZDWTKFDAUOODA-CNEMSGBDSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64081 provides the N6-benzoyl-protected adenosine identity for RNA building-block and nucleoside chemistry research.
Synonyms
N6-Benzoyladenosine; N6-Bz-rA; rABz
Identity and specifications
| Catalog No. | CH64081 |
| CAS No. | 4546-55-8 |
| Molecular Formula | C17H17N5O5 |
| Molecular Weight | 371.35 |
| PubChem CID | 11728391 |
| InChIKey | NZDWTKFDAUOODA-CNEMSGBDSA-N |
| Purity | >=98% |
Storage conditions
Room temperature; recommended cool and dark below 15 C
Technical attributes
- Nucleobase
- Adenine
- Sugar
- D-Ribose
- Base protection
- N6-Benzoyl
- Synthesis role
- Base-protected RNA nucleoside intermediate
- Packaging
- 1 g; 5 g; Custom packaging on request
- Water content
- <=8.0%
- Physical form
- solid; white to almost white powder to crystal
Application context
- Base-protected RNA building block: the N6-benzoyl group masks the adenine exocyclic amine in RNA oligonucleotide-synthesis chemistry and is removed during deprotection.
- Adenosine (rA) monomer precursor context: CH64081 is the base-protected adenosine identity relevant to adenine building-block preparation.
- Nucleoside chemistry reference: CH64081 provides the N6-benzoyladenosine (rABz) identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 11728391
PubChem · CID 11728391
Frequently Asked Questions
Why is the N6-amine of this adenosine benzoylated?
In RNA oligonucleotide synthesis the reactive exocyclic amine of adenine is masked with a protecting group such as benzoyl to prevent side reactions; the benzoyl group is later removed during deprotection.
How does it differ from N6-benzoyl-2'-deoxyadenosine?
Both carry an N6-benzoyl-protected adenine, but this one is the ribonucleoside (2'-OH), while N6-benzoyl-2'-deoxyadenosine is the 2'-deoxy form. Both are cataloged separately.
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