N4-Benzoylcytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C16H17N3O6
- MW
- 347.32
- Purity
- 99%
N4-Benzoylcytidine (rCBz) is cytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64082 is identified by CAS 13089-48-0, molecular formula C16H17N3O6, molecular weight 347.32, PubChem CID 10066259, and InChIKey BNXBRFDWSPXODM-BPGGGUHBSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64082 provides the N4-benzoyl-protected cytidine identity for RNA building-block and nucleoside chemistry research.
Synonyms
N4-Benzoylcytidine; N4-Bz-rC; rCBz
Identity and specifications
| Catalog No. | CH64082 |
| CAS No. | 13089-48-0 |
| Molecular Formula | C16H17N3O6 |
| Molecular Weight | 347.32 |
| PubChem CID | 10066259 |
| InChIKey | BNXBRFDWSPXODM-BPGGGUHBSA-N |
| Purity | 99% |
Storage conditions
Room temperature; recommended cool and dark below 15 C; store under inert gas; hygroscopic
Technical attributes
- Nucleobase
- Cytosine
- Sugar
- D-Ribose
- Base protection
- N4-Benzoyl
- Synthesis role
- Base-protected RNA nucleoside intermediate
- Packaging
- 1 g; 5 g; Custom packaging on request
- Physical form
- solid; white to almost white powder to crystal
Application context
- Base-protected RNA building block: the N4-benzoyl group masks the cytosine exocyclic amine in RNA oligonucleotide-synthesis chemistry and is removed during deprotection.
- Cytidine (rC) monomer precursor context: CH64082 is the base-protected cytidine identity relevant to cytosine building-block preparation.
- Nucleoside chemistry reference: CH64082 provides the N4-benzoylcytidine (rCBz) identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 10066259
PubChem · CID 10066259
Frequently Asked Questions
Why is the N4-amine of this cytidine benzoylated?
In RNA oligonucleotide synthesis the reactive exocyclic amine of cytosine is masked with a protecting group such as benzoyl to prevent side reactions; the benzoyl group is later removed during deprotection.
How does it differ from N4-benzoyl-2'-deoxycytidine?
Both carry an N4-benzoyl-protected cytosine, but this one is the ribonucleoside (2'-OH), while N4-benzoyl-2'-deoxycytidine is the 2'-deoxy form. Both are cataloged separately.
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