N2-Isobutyrylguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C14H19N5O6
- MW
- 353.33
- Purity
- 95%
N2-Isobutyrylguanosine (rGiBu) is guanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64083 is identified by CAS 64350-24-9, molecular formula C14H19N5O6, molecular weight 353.33, PubChem CID 135722152, and InChIKey OXTYJSXVUGJSGM-HTVVRFAVSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64083 provides the N2-isobutyryl-protected guanosine identity for RNA building-block and nucleoside chemistry research.
Synonyms
N2-Isobutyrylguanosine; N2-ibu-rG; rGiBu
Identity and specifications
| Catalog No. | CH64083 |
| CAS No. | 64350-24-9 |
| Molecular Formula | C14H19N5O6 |
| Molecular Weight | 353.33 |
| PubChem CID | 135722152 |
| InChIKey | OXTYJSXVUGJSGM-HTVVRFAVSA-N |
| Purity | 95% |
Storage conditions
Refrigerator
Technical attributes
- Nucleobase
- Guanine
- Sugar
- D-Ribose
- Base protection
- N2-Isobutyryl
- Synthesis role
- Base-protected RNA nucleoside intermediate
- Packaging
- 1 g; 5 g; 10 g; Custom packaging on request
- Physical form
- crystal-powder; white to almost white
Application context
- Base-protected RNA building block: the N2-isobutyryl group masks the guanine exocyclic amine in RNA oligonucleotide-synthesis chemistry and is removed during deprotection.
- Guanosine (rG) monomer precursor context: CH64083 is the base-protected guanosine identity relevant to guanine building-block preparation.
- Nucleoside chemistry reference: CH64083 provides the N2-isobutyrylguanosine (rGiBu) identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135722152
PubChem · CID 135722152
Frequently Asked Questions
Why is the N2-amine of this guanosine protected with isobutyryl?
In RNA oligonucleotide synthesis the reactive exocyclic amine of guanine is masked with a protecting group such as isobutyryl to prevent side reactions; the isobutyryl group is later removed during deprotection.
How does it differ from N2-isobutyryl-2'-deoxyguanosine?
Both carry an N2-isobutyryl-protected guanine, but this one is the ribonucleoside (2'-OH), while N2-isobutyryl-2'-deoxyguanosine is the 2'-deoxy form. Both are cataloged separately.
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