N6-Methyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H15N5O4
- MW
- 281.27
- Purity
- 99.75%
N6-Methyladenosine (m6A) is adenosine methylated at the adenine N6 position, corresponding to the nucleoside form of the RNA modification m6A. CH64084 is identified by CAS 1867-73-8, molecular formula C11H15N5O4, molecular weight 281.27, PubChem CID 102175, and InChIKey VQAYFKKCNSOZKM-IOSLPCCCSA-N.
The cited literature discusses m6A as the most abundant internal modification in mRNA and as an epitranscriptomic mark. Unlike acyl-protected building blocks, the N6-methyl group is a permanent base modification, not a removable protecting group.
Synonyms
N6-Methyladenosine; m6A; N6-methyl-rA
Identity and specifications
| Catalog No. | CH64084 |
| CAS No. | 1867-73-8 |
| Molecular Formula | C11H15N5O4 |
| Molecular Weight | 281.27 |
| PubChem CID | 102175 |
| InChIKey | VQAYFKKCNSOZKM-IOSLPCCCSA-N |
| Purity | 99.75% |
Storage conditions
-20 C
Technical attributes
- Nucleobase
- Adenine
- Sugar
- D-Ribose
- Base modification
- N6-Methyl (m6A)
- Research role
- RNA epitranscriptomic-mark nucleoside reference
- Packaging
- 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; solid-plus-solvent kit: 1 mL reconstitution volume; Solid: 25 mg; supplied solution: 1 mL; Custom packaging on request
- Solution concentration
- Supplied solution: 10 mM x 1 mL in DMSO; solid-plus-solvent kit: 10 mM x 1 mL in DMSO ready for reconstitution
- Physical form
- crystalline solid
- Stability
- >=4 years
Application context
- m6A epitranscriptomic-mark research: CH64084 is the nucleoside form of m6A, the RNA modification discussed in the cited literature as the most abundant internal mRNA modification.
- Base-modified nucleoside reference: CH64084 provides the N6-methyladenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 102175
PubChem · CID 102175
Frequently Asked Questions
Is the N6-methyl group a protecting group?
No. Unlike N6-acyl building blocks such as benzoyl- or 4-methoxybenzoyl-protected adenosine, the N6-methyl here is a permanent base modification and is not removed during deprotection.
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