N2-Phenoxyacetylguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C18H19N5O7
- MW
- 417.37
- Purity
- >=98%
N2-Phenoxyacetylguanosine (rG PAc) is guanosine whose guanine exocyclic N2-amine is protected with a phenoxyacetyl (PAc) group. CH64085 is identified by CAS 119824-66-7, molecular formula C18H19N5O7, molecular weight 417.37, PubChem CID 135921574, and InChIKey FOOYAXZEBFXEJD-IWCJZZDYSA-N.
The cited oligonucleotide-synthesis literature discusses labile exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64085 provides the N2-phenoxyacetyl-protected guanosine identity for RNA building-block and nucleoside chemistry research.
Synonyms
N2-Phenoxyacetylguanosine; N2-PAc-rG; rG(PAc)
Identity and specifications
| Catalog No. | CH64085 |
| CAS No. | 119824-66-7 |
| Molecular Formula | C18H19N5O7 |
| Molecular Weight | 417.37 |
| PubChem CID | 135921574 |
| InChIKey | FOOYAXZEBFXEJD-IWCJZZDYSA-N |
| Purity | >=98% |
Technical attributes
- Nucleobase
- Guanine
- Sugar
- D-Ribose
- Base protection
- N2-Phenoxyacetyl (PAc)
- Synthesis role
- Base-protected RNA nucleoside intermediate
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g; 25 g; 100 g; Custom packaging on request
Application context
- Base-protected RNA building block: the N2-phenoxyacetyl (PAc) group masks the guanine exocyclic amine in RNA oligonucleotide-synthesis chemistry and is removed during deprotection.
- Guanosine (rG) monomer precursor context: CH64085 is the PAc-protected guanosine identity relevant to guanine building-block preparation.
- Nucleoside chemistry reference: CH64085 provides the N2-phenoxyacetylguanosine (rG PAc) identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135921574
PubChem · CID 135921574
Frequently Asked Questions
What is the 'PAc' group on this guanosine?
PAc is phenoxyacetyl. In CH64085, the group is on the guanine exocyclic N2-amine and is part of the base-protected guanosine identity.
How does it differ from N2-isobutyrylguanosine?
Both protect the guanine N2-amine, but this one uses a phenoxyacetyl (PAc) group rather than isobutyryl. N2-isobutyrylguanosine is cataloged separately.
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