N6-Benzoyl-2'-O-methyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C18H19N5O5
- MW
- 385.37
- Purity
- >=98.0% (HPLC)
N6-Benzoyl-2'-O-methyladenosine is 2'-O-methyladenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64086 is identified by CAS 85079-00-1, molecular formula C18H19N5O5, molecular weight 385.37, PubChem CID 13852840, and InChIKey PHFHSPQCDRKMQJ-XWXWGSFUSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
Synonyms
N6-Benzoyl-2'-O-methyladenosine; N6-Bz-2'-OMe-rA; 2'-OMe-rA(Bz)
Identity and specifications
| Catalog No. | CH64086 |
| CAS No. | 85079-00-1 |
| Molecular Formula | C18H19N5O5 |
| Molecular Weight | 385.37 |
| PubChem CID | 13852840 |
| InChIKey | PHFHSPQCDRKMQJ-XWXWGSFUSA-N |
| Purity | >=98.0% (HPLC) |
Storage conditions
2-8 C; keep dark and dry
Technical attributes
- Nucleobase
- Adenine
- Sugar modification
- 2'-O-Methyl
- Base protection
- N6-Benzoyl
- Synthesis role
- Base-protected 2'-O-methyl nucleoside intermediate
- Packaging
- 1 g; 5 g; Custom packaging on request
- Water content
- <=6.0%
- Physical form
- white powder
Application context
- Base-protected 2'-OMe building block: the N6-benzoyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
- Nucleoside chemistry reference: CH64086 provides the N6-benzoyl-2'-O-methyladenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 13852840
PubChem · CID 13852840
Frequently Asked Questions
How does it differ from N6-benzoyladenosine?
Both carry an N6-benzoyl-protected adenine, but this one also has a 2'-O-methyl sugar modification, whereas N6-benzoyladenosine has a free 2'-OH. N6-benzoyladenosine is cataloged separately.
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