N4-Benzoyl-2'-O-methylcytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C17H19N3O6
- MW
- 361.35
- Purity
- 99.21%
N4-Benzoyl-2'-O-methylcytidine is 2'-O-methylcytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64087 is identified by CAS 52571-45-6, molecular formula C17H19N3O6, molecular weight 361.35, PubChem CID 13852838, and InChIKey LIZIIHWLABYQKD-XKVFNRALSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
Synonyms
N4-Benzoyl-2'-O-methylcytidine; N4-Bz-2'-OMe-rC; 2'-OMe-rC(Bz)
Identity and specifications
| Catalog No. | CH64087 |
| CAS No. | 52571-45-6 |
| Molecular Formula | C17H19N3O6 |
| Molecular Weight | 361.35 |
| PubChem CID | 13852838 |
| InChIKey | LIZIIHWLABYQKD-XKVFNRALSA-N |
| Purity | 99.21% |
Storage conditions
2-8 C
Technical attributes
- Nucleobase
- Cytosine
- Sugar modification
- 2'-O-Methyl
- Base protection
- N4-Benzoyl
- Synthesis role
- Base-protected 2'-O-methyl nucleoside intermediate
- Packaging
- 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 50 g; solid-plus-solvent kit: 1 mL reconstitution volume; Solid: 100 mg; supplied solution: 1 mL; Custom packaging on request
- Solution concentration
- Supplied solution: 10 mM x 1 mL in DMSO; solid-plus-solvent kit: 10 mM x 1 mL in DMSO ready for reconstitution
- Water content
- <=2.0%
- Physical form
- white to off-white powder
Application context
- Base-protected 2'-OMe building block: the N4-benzoyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
- Nucleoside chemistry reference: CH64087 provides the N4-benzoyl-2'-O-methylcytidine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 13852838
PubChem · CID 13852838
Frequently Asked Questions
How does it differ from N4-benzoylcytidine?
Both carry an N4-benzoyl-protected cytosine, but this one also has a 2'-O-methyl sugar modification, whereas N4-benzoylcytidine has a free 2'-OH. N4-benzoylcytidine is cataloged separately.
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