N6-Benzoyl-2'-fluoro-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C17H16FN5O4
- MW
- 373.34
- Purity
- 99.92%
N6-Benzoyl-2'-fluoro-2'-deoxyadenosine is 2'-fluoro-2'-deoxyadenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64091 is identified by CAS 136834-20-3, molecular formula C17H16FN5O4, molecular weight 373.34, PubChem CID 11760510, and InChIKey HLJZTLWDAQVZBU-YAMOITTJSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Synonyms
N6-Benzoyl-2'-fluoro-2'-deoxyadenosine; N6-Bz-2'-F-dA; 2'-F-rA(Bz)
Identity and specifications
| Catalog No. | CH64091 |
| CAS No. | 136834-20-3 |
| Molecular Formula | C17H16FN5O4 |
| Molecular Weight | 373.34 |
| PubChem CID | 11760510 |
| InChIKey | HLJZTLWDAQVZBU-YAMOITTJSA-N |
| Purity | 99.92% |
Storage conditions
2-8 C; keep dark and dry
Technical attributes
- Nucleobase
- Adenine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N6-Benzoyl
- Synthesis role
- Base-protected 2'-fluoro nucleoside intermediate
- Packaging
- 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; solution 1 mL x 10 mM in DMSO; Custom packaging on request
- Solution concentration
- 10 mM in DMSO
- Water content
- <=2.0%
- Physical form
- white powder
- Stability
- Powder: 3 years at -20 C or 2 years at 4 C; in solvent: 6 months at -80 C or 1 month at -20 C
Application context
- Base-protected 2'-F building block: the N6-benzoyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-Fluoro sugar modification context: cited 2'-fluoro oligonucleotide literature discusses RNA affinity and nuclease resistance.
- Nucleoside chemistry reference: CH64091 provides the N6-benzoyl-2'-fluoro-2'-deoxyadenosine identity for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 11760510
PubChem · CID 11760510
Frequently Asked Questions
How does it differ from N6-benzoyl-2'-O-methyladenosine?
Both are N6-benzoyl base-protected adenosines, but this one has a 2'-fluoro sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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