N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C14H18FN5O5
- MW
- 355.32
- Purity
- >=98.0% (HPLC)
N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine is 2'-fluoro-2'-deoxyguanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64093 is identified by CAS 80681-25-0, molecular formula C14H18FN5O5, molecular weight 355.32, PubChem CID 135742141, and InChIKey SLHADUUWJSVYGQ-HTFXMJNNSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Synonyms
N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine; N2-ibu-2'-F-dG; 2'-F-rG(iBu)
Identity and specifications
| Catalog No. | CH64093 |
| CAS No. | 80681-25-0 |
| Molecular Formula | C14H18FN5O5 |
| Molecular Weight | 355.32 |
| PubChem CID | 135742141 |
| InChIKey | SLHADUUWJSVYGQ-HTFXMJNNSA-N |
| Purity | >=98.0% (HPLC) |
Storage conditions
2-8 C; keep dark and dry
Technical attributes
- Nucleobase
- Guanine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N2-Isobutyryl
- Synthesis role
- Base-protected 2'-fluoro nucleoside intermediate
- Packaging
- Custom packaging on request
- Water content
- <=2.0%
- Physical form
- white powder
Application context
- Base-protected 2'-F building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-Fluoro sugar modification context: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- Nucleoside chemistry identity: a defined N2-isobutyryl-2'-fluoro-2'-deoxyguanosine compound for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135742141
PubChem · CID 135742141
Frequently Asked Questions
How does it differ from N2-isobutyryl-2'-O-methylguanosine?
Both are N2-isobutyryl base-protected guanosines, but this one has a 2'-fluoro sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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