N4-Acetyl-2'-fluoro-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H14FN3O5
- MW
- 287.24
- Purity
- >=99.0% (HPLC)
N4-Acetyl-2'-fluoro-2'-deoxycytidine is 2'-fluoro-2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with an acetyl group. CH64094 is identified by CAS 159414-97-8, molecular formula C11H14FN3O5, molecular weight 287.24, PubChem CID 22094552, and InChIKey NLXVKEFNBVLDLD-PEBGCTIMSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Synonyms
N4-Acetyl-2'-fluoro-2'-deoxycytidine; N4-Ac-2'-F-dC; 2'-F-rC(Ac)
Identity and specifications
| Catalog No. | CH64094 |
| CAS No. | 159414-97-8 |
| Molecular Formula | C11H14FN3O5 |
| Molecular Weight | 287.24 |
| PubChem CID | 22094552 |
| InChIKey | NLXVKEFNBVLDLD-PEBGCTIMSA-N |
| Purity | >=99.0% (HPLC) |
Storage conditions
2-8 C; keep dark and dry
Technical attributes
- Nucleobase
- Cytosine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N4-Acetyl
- Synthesis role
- Base-protected 2'-fluoro nucleoside intermediate
- Packaging
- Custom packaging on request
- Water content
- <=5.0%
- Physical form
- white powder
- Stability
- In solvent: 6 months at -80 C or 1 month at -20 C
Application context
- Base-protected 2'-F building block: the N4-acetyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-Fluoro sugar modification context: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- Nucleoside chemistry identity: a defined N4-acetyl-2'-fluoro-2'-deoxycytidine compound for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 22094552
PubChem · CID 22094552
Frequently Asked Questions
How does it differ from N4-benzoyl-2'-fluoro-2'-deoxycytidine?
Both are 2'-fluoro cytidines with a protected cytosine N4-amine, but this one uses an acetyl group rather than benzoyl. The benzoyl form is cataloged separately.
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