2'-O-MOE-N2-Isobutyrylguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C17H25N5O7
- MW
- 411.41
- Purity
- >=98%
2'-O-MOE-N2-Isobutyrylguanosine is 2'-O-(2-methoxyethyl)guanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64098 is identified by CAS 440327-50-4, molecular formula C17H25N5O7, molecular weight 411.41, PubChem CID 136162613, and InChIKey IZOOGJIUOCHAAY-UBEDBUPSSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.
Synonyms
2'-O-MOE-N2-Isobutyrylguanosine; 2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine; MOE-rG(iBu)
Identity and specifications
| Catalog No. | CH64098 |
| CAS No. | 440327-50-4 |
| Molecular Formula | C17H25N5O7 |
| Molecular Weight | 411.41 |
| PubChem CID | 136162613 |
| InChIKey | IZOOGJIUOCHAAY-UBEDBUPSSA-N |
| Purity | >=98% |
Storage conditions
2-8 C
Technical attributes
- Nucleobase
- Guanine
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Base protection
- N2-Isobutyryl
- Synthesis role
- Base-protected MOE nucleoside intermediate
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 10 g; 100 g; 1 kg; Custom packaging on request
- Water content
- <=2.0%
- Physical form
- white to off-white powder
- Stability
- Powder: 3 years at -20 C; in solvent: 1 year at -80 C
Application context
- Base-protected 2'-O-MOE building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-O-MOE modification context: cited structure and stability literature discusses 2'-O-MOE residues in relation to RNA affinity, nuclease resistance, and gapmer flanking residues.
- Nucleoside chemistry identity: a defined 2'-O-MOE-N2-isobutyrylguanosine compound for nucleoside chemistry research.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 136162613
PubChem · CID 136162613
Frequently Asked Questions
How does it differ from N2-isobutyryl-2'-O-methylguanosine?
Both are N2-isobutyryl base-protected guanosines, but this one has a 2'-O-methoxyethyl (2'-MOE) sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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