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Oligonucleotide Synthesis, RNA Raw Materials & Modification

5'-O-DMT-2'-deoxyinosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

Product NoCH64106CAS No93778-57-5Purity99.40%
5'-O-DMT-2'-deoxyinosine

Product summary

Quick view

Product family
Oligonucleotide Synthesis, RNA Raw Materials & Modification
MF
C31H30N4O6
MW
554.60
Purity
99.40%

5'-O-DMT-2'-deoxyinosine is 2'-deoxyinosine (hypoxanthine base) carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group. CH64106 is identified by CAS 93778-57-5, molecular formula C31H30N4O6, molecular weight 554.60, PubChem CID 136192437, and InChIKey IYNGMVFRUKBGNM-OYUWMTPXSA-N.

It is a 5'-protected precursor for DNA phosphoramidite/oligonucleotide synthesis: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle. Because the hypoxanthine base has no exocyclic amine, no base protecting group is required.

Synonyms

5'-O-DMT-2'-deoxyinosine; 5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine; DMT-dI

Identity and specifications

Catalog No.CH64106
CAS No.93778-57-5
Molecular FormulaC31H30N4O6
Molecular Weight554.60
PubChem CID136192437
InChIKeyIYNGMVFRUKBGNM-OYUWMTPXSA-N
Purity99.40%

Storage conditions

-20 C long-term

Technical attributes

Nucleobase
Hypoxanthine
Sugar
2'-Deoxyribose
5'-O protection
DMT (dimethoxytrityl)
Base protection
Unprotected
Grade
N (Normal)
Packaging
5 g; 10 g; 50 g; Custom packaging on request
Water content
<=1.0%
Physical form
white to faint yellow powder
Stability
Prepared stock solution: 6 months at -80 C or 1 month at -20 C

Application context

  • 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each oligonucleotide chain-elongation cycle.
  • No base protection needed: the hypoxanthine base has no exocyclic amine, so this building block requires no base protecting group.
  • Phosphoramidite precursor context: a 5'-protected 2'-deoxyinosine precursor toward DNA phosphoramidite building blocks.

Public references

Frequently Asked Questions

Why does 5'-O-DMT-2'-deoxyinosine have no base protecting group?

The hypoxanthine base of 2'-deoxyinosine has no reactive exocyclic amine, so it needs no base protection. Only the 5'-hydroxyl is protected with the acid-labile DMT group, which is removed at the start of each oligonucleotide chain-elongation cycle.

What base does 2'-deoxyinosine contain?

It contains hypoxanthine, the deaminated form of the adenine base. This record is the 5'-O-DMT-protected precursor.

What identifiers should match for CH64106?

Match CAS 93778-57-5, molecular formula C31H30N4O6, molecular weight 554.60, PubChem CID 136192437, and InChIKey IYNGMVFRUKBGNM-OYUWMTPXSA-N.

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