5'-O-DMT-2'-fluoro-N6-benzoyl-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C38H34FN5O6
- MW
- 675.7
- Purity
- 99.58%
5'-O-DMT-2'-fluoro-N6-benzoyl-2'-deoxyadenosine is 2'-fluoro-2'-deoxyadenosine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group and an N6-benzoyl base-protecting group. CH64122 is identified by CAS 136834-21-4, molecular formula C38H34FN5O6, molecular weight 675.7, PubChem CID 11125261, and InChIKey DDOOVEXTSRBCMU-VYUOYPLNSA-N.
It is a 2'-F-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle, and the N6-benzoyl group masks the adenine exocyclic amine and is removed at final deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Synonyms
5'-O-DMT-2'-fluoro-N6-benzoyl-2'-deoxyadenosine; 5'-O-DMT-2'-F-rA(Bz); DMT-2'-F-rA(Bz)
Identity and specifications
| Catalog No. | CH64122 |
| CAS No. | 136834-21-4 |
| Molecular Formula | C38H34FN5O6 |
| Molecular Weight | 675.7 |
| PubChem CID | 11125261 |
| InChIKey | DDOOVEXTSRBCMU-VYUOYPLNSA-N |
| Purity | 99.58% |
Storage conditions
2-8 C
Technical attributes
- Nucleobase
- Adenine
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N6-Benzoyl
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 1 kg; 1 mL; Custom packaging on request
- Solution concentration
- 10 mM in DMSO
- Water content
- <=1.0%
- Physical form
- white to off-white powder
- Stability
- Powder: 3 years at -20 C; in solvent: 1 year at -80 C
Application context
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-Fluoro sugar modification: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- N6-benzoyl base protection: the benzoyl group masks the adenine exocyclic amine during synthesis and is removed at final deprotection.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 11125261
PubChem · CID 11125261
Frequently Asked Questions
How does it differ from N6-benzoyl-2'-fluoro-2'-deoxyadenosine?
Both carry an N6-benzoyl-protected 2'-fluoro adenosine, but this one also has a 5'-O-DMT group on the 5'-hydroxyl (as a phosphoramidite precursor). The non-DMT form is cataloged separately.
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