5'-O-DMT-2'-O-MOE-N6-benzoyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C41H41N5O8
- MW
- 731.8
- Purity
- >=99%
5'-O-DMT-2'-O-MOE-N6-benzoyladenosine is 2'-O-(2-methoxyethyl)adenosine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group and an N6-benzoyl base-protecting group. CH64126 is identified by CAS 251647-48-0, molecular formula C41H41N5O8, molecular weight 731.8, PubChem CID 21107951, and InChIKey KEVMXGNDTKPSMC-MUMPVVMASA-N.
It is a 2'-O-MOE-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle, and the N6-benzoyl group masks the adenine exocyclic amine and is removed at final deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.
Synonyms
5'-O-DMT-2'-O-MOE-N6-benzoyladenosine; 5'-O-DMT-2'-O-(2-methoxyethyl)-N6-Bz-rA; DMT-2'-MOE-rA(Bz)
Identity and specifications
| Catalog No. | CH64126 |
| CAS No. | 251647-48-0 |
| Molecular Formula | C41H41N5O8 |
| Molecular Weight | 731.8 |
| PubChem CID | 21107951 |
| InChIKey | KEVMXGNDTKPSMC-MUMPVVMASA-N |
| Purity | >=99% |
Storage conditions
2-8 C, tightly closed, protected from light and humidity
Technical attributes
- Nucleobase
- Adenine
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Base protection
- N6-Benzoyl
- Grade
- N (Normal)
- Packaging
- 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; Custom packaging on request
- Water content
- <=1.0%
- Physical form
- white, off-white to faint yellow powder
Application context
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-MOE sugar modification: cited structure and stability literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies.
- N6-benzoyl base protection: the benzoyl group masks the adenine exocyclic amine during synthesis and is removed at final deprotection.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 21107951
PubChem · CID 21107951
Frequently Asked Questions
How does it differ from 2'-O-MOE-N6-benzoyladenosine?
Both carry an N6-benzoyl-protected 2'-O-MOE adenosine, but this one also has a 5'-O-DMT group on the 5'-hydroxyl (as a phosphoramidite precursor). The non-DMT form is cataloged separately.
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