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Oligonucleotide Synthesis, RNA Raw Materials & Modification

5'-O-DMT-2'-O-MOE-N6-benzoyladenosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

Product NoCH64126CAS No251647-48-0Purity>=99%
5'-O-DMT-2'-O-MOE-N6-benzoyladenosine

Product summary

Quick view

Product family
Oligonucleotide Synthesis, RNA Raw Materials & Modification
MF
C41H41N5O8
MW
731.8
Purity
>=99%

5'-O-DMT-2'-O-MOE-N6-benzoyladenosine is 2'-O-(2-methoxyethyl)adenosine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group and an N6-benzoyl base-protecting group. CH64126 is identified by CAS 251647-48-0, molecular formula C41H41N5O8, molecular weight 731.8, PubChem CID 21107951, and InChIKey KEVMXGNDTKPSMC-MUMPVVMASA-N.

It is a 2'-O-MOE-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle, and the N6-benzoyl group masks the adenine exocyclic amine and is removed at final deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.

Synonyms

5'-O-DMT-2'-O-MOE-N6-benzoyladenosine; 5'-O-DMT-2'-O-(2-methoxyethyl)-N6-Bz-rA; DMT-2'-MOE-rA(Bz)

Identity and specifications

Catalog No.CH64126
CAS No.251647-48-0
Molecular FormulaC41H41N5O8
Molecular Weight731.8
PubChem CID21107951
InChIKeyKEVMXGNDTKPSMC-MUMPVVMASA-N
Purity>=99%

Storage conditions

2-8 C, tightly closed, protected from light and humidity

Technical attributes

Nucleobase
Adenine
5'-O protection
DMT (dimethoxytrityl)
Sugar modification
2'-O-(2-Methoxyethyl) (MOE)
Base protection
N6-Benzoyl
Grade
N (Normal)
Packaging
25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; Custom packaging on request
Water content
<=1.0%
Physical form
white, off-white to faint yellow powder

Application context

  • 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
  • 2'-MOE sugar modification: cited structure and stability literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies.
  • N6-benzoyl base protection: the benzoyl group masks the adenine exocyclic amine during synthesis and is removed at final deprotection.

Public references

Frequently Asked Questions

How does it differ from 2'-O-MOE-N6-benzoyladenosine?

Both carry an N6-benzoyl-protected 2'-O-MOE adenosine, but this one also has a 5'-O-DMT group on the 5'-hydroxyl (as a phosphoramidite precursor). The non-DMT form is cataloged separately.

What identifiers should match for CH64126?

Match CAS 251647-48-0, molecular formula C41H41N5O8, molecular weight 731.8, PubChem CID 21107951, and InChIKey KEVMXGNDTKPSMC-MUMPVVMASA-N.

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