Morpholino G Subunit (PMO)
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C43H46ClN8O7P
- MW
- 853.3
- Purity
- >=99%
Morpholino G Subunit is the guanine building block for phosphorodiamidate morpholino oligomer (PMO) synthesis. It is a morpholine ring bearing a base-protected guanine, a trityl-protected morpholine nitrogen, and an activated phosphorodiamidochloridate coupling group. CH65043 is identified by CAS 2504201-88-9, molecular formula C43H46ClN8O7P, molecular weight 853.3, PubChem CID 163284823, and InChIKey WAHZVPMCAUKPIH-UHFFFAOYSA-N.
PMOs are nonionic DNA analogs in which a morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate. This activated subunit provides the guanine morpholino subunit identity for PMO assembly.
Synonyms
PMO guanine subunit; morpholino guanosine chlorophosphoramidate subunit
Identity and specifications
| Catalog No. | CH65043 |
| CAS No. | 2504201-88-9 |
| Molecular Formula | C43H46ClN8O7P |
| Molecular Weight | 853.3 |
| PubChem CID | 163284823 |
| InChIKey | WAHZVPMCAUKPIH-UHFFFAOYSA-N |
| Purity | >=99% |
Storage conditions
-20 C; tightly closed, dry, and well ventilated
Technical attributes
- Monomer class
- PMO morpholino subunit
- Nucleobase
- Guanine
- Backbone scaffold
- Morpholine
- Activated group
- Phosphorodiamidochloridate
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; Custom packaging on request
- Physical form
- off-white solid
- Stability
- stable under recommended storage conditions; avoid moisture
Application context
- PMO guanine building block: provides the guanine morpholino subunit identity for phosphorodiamidate morpholino oligomer (PMO) synthesis.
- Morpholino backbone: the morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate, giving a nonionic oligomer.
- Protected, activated subunit: the guanine base is protected, the morpholine nitrogen is trityl-protected, and the phosphorodiamidochloridate is the reactive coupling group.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 163284823
PubChem · CID 163284823
Frequently Asked Questions
What is a morpholino (PMO) subunit?
It is a building block for phosphorodiamidate morpholino oligomers (PMOs), nonionic DNA analogs in which a morpholine ring replaces the ribose and phosphorodiamidate linkages replace the phosphates. This product provides the guanine morpholino subunit identity.
How is it protected and activated?
The guanine base is protected, the morpholine nitrogen is trityl-protected, and the reactive phosphorodiamidochloridate group is the coupling handle for PMO chain extension.
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