UNA-G(iBu) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C51H60N7O10P
- MW
- 962.0
- Purity
- >=98.0% (HPLC)
UNA-G(iBu) CE Phosphoramidite is the unlocked nucleic acid (UNA) guanine building block for oligonucleotide synthesis: an acyclic (C2'-C3' bond-opened) ribonucleoside bearing an N2-isobutyryl guanine, a 5'-O-(4,4'-dimethoxytrityl) group, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65061 is identified by CAS 1120329-61-4, molecular formula C51H60N7O10P, molecular weight 962.0, PubChem CID 138376032, and InChIKey PCZJDFIZVYBABW-WESQYFQMSA-N.
The cited UNA literature discusses unlocked acyclic nucleic acid structures in relation to duplex characteristics. As a phosphoramidite, the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.
Synonyms
UNA-G(iBu) phosphoramidite; DMT-unlocked-N2-isobutyrylguanosine CE phosphoramidite
Identity and specifications
| Catalog No. | CH65061 |
| CAS No. | 1120329-61-4 |
| Molecular Formula | C51H60N7O10P |
| Molecular Weight | 962.0 |
| PubChem CID | 138376032 |
| InChIKey | PCZJDFIZVYBABW-WESQYFQMSA-N |
| Purity | >=98.0% (HPLC) |
Storage conditions
-20 C
Technical attributes
- Monomer class
- UNA CE phosphoramidite
- Nucleobase
- Guanine
- Sugar topology
- C2'-C3' bond-opened ribose
- Base protection
- N2-isobutyryl
- Grade
- N (Normal)
- Packaging
- 10 mg; 50 mg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- powder 3 years; in solvent 1 year
Application context
- UNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- Unlocked acyclic modification: the cited UNA literature discusses C2'-C3' bond-opened ribose structures in relation to oligonucleotide duplex characteristics.
- 5'-DMT + N2-isobutyryl protection: the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 138376032
PubChem · CID 138376032
Frequently Asked Questions
How does it differ from the UNA-A(Bz) amidite?
Both are UNA (unlocked) phosphoramidites, but this one has an N2-isobutyryl-protected guanine, whereas the UNA-A(Bz) amidite has an N6-benzoyl adenine. Each UNA base is cataloged separately.
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