UNA-U CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C46H53N4O10P
- MW
- 852.9
- Purity
- 99%
UNA-U CE Phosphoramidite is the unlocked nucleic acid (UNA) uracil building block for oligonucleotide synthesis: an acyclic (C2'-C3' bond-opened) ribonucleoside bearing a uracil base, a 5'-O-(4,4'-dimethoxytrityl) group, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65062 is identified by CAS 1120329-48-7, molecular formula C46H53N4O10P, molecular weight 852.9, PubChem CID 100942372, and InChIKey MHRGEJFLFYZLJI-LZOZAVILSA-N.
The cited UNA literature discusses unlocked acyclic nucleic acid structures in relation to duplex characteristics. As a phosphoramidite, the 3'-phosphoramidite couples to the growing chain and the acid-labile 5'-DMT is removed each cycle. Because uracil has no exocyclic amine, no base protecting group is required.
Synonyms
UNA-U phosphoramidite; DMT-unlocked-uridine CE phosphoramidite
Identity and specifications
| Catalog No. | CH65062 |
| CAS No. | 1120329-48-7 |
| Molecular Formula | C46H53N4O10P |
| Molecular Weight | 852.9 |
| PubChem CID | 100942372 |
| InChIKey | MHRGEJFLFYZLJI-LZOZAVILSA-N |
| Purity | 99% |
Storage conditions
-20 C
Technical attributes
- Monomer class
- UNA CE phosphoramidite
- Nucleobase
- Uracil
- Sugar topology
- C2'-C3' bond-opened ribose
- Base protection
- None required
- Grade
- N (Normal)
- Packaging
- 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; 5 kg; 10 kg; 25 kg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
Application context
- UNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- Unlocked acyclic modification: the cited UNA literature discusses C2'-C3' bond-opened ribose structures in relation to oligonucleotide duplex characteristics.
- No base protection needed: uracil has no exocyclic amine, so this monomer requires no base protecting group (only the acid-labile 5'-DMT, removed each cycle).
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 100942372
PubChem · CID 100942372
Frequently Asked Questions
Why does the UNA-U amidite have no base protecting group?
Uracil has no reactive exocyclic amine, so it needs no base protection. The monomer carries only the acid-labile 5'-O-DMT group (removed each cycle) and the reactive phosphoramidite coupling group.
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