5-aa-UTP (Aminoallyl-UTP)
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Purity
- >95% (HPLC, UV)
5-aa-UTP is 5-(3-aminoallyl)-uridine-5'-triphosphate, commonly described as aminoallyl-UTP. It is an amine-modified ribonucleotide triphosphate and the UTP counterpart of aminoallyl-dUTP. Key identifiers for this catalog entry are CHEMOS CH66012 and CAS 75221-88-4.
In enzymatic RNA labeling workflows, aminoallyl-UTP can be incorporated during in vitro transcription to introduce a primary amine into RNA. The amine can then react with amine-reactive reporters such as NHS-ester dyes, enabling post-synthetic transcript labeling. This page keeps the identity boundary to the supplier catalog name, CAS number, and literature-supported aminoallyl-UTP use context.
Synonyms
aminoallyl-UTP; 5-(3-aminoallyl)-uridine-5'-triphosphate; AA-UTP
Identity and specifications
| Catalog No. | CH66012 |
| Product Name | 5-aa-UTP (Aminoallyl-UTP) |
| CAS No. | 75221-88-4 |
| Product Type | Amine-modified ribonucleotide triphosphate |
| Labeling Handle | 5-aminoallyl primary amine |
| Purity | >95% (HPLC, UV) |
Storage conditions
freeze below -15 C; minimize light exposure
Technical attributes
- Nucleotide class
- rNTP
- Parent nucleotide
- UTP
- Base modification
- 5-(3-Aminoallyl)
- Reactive handle
- Primary amine
- Packaging
- 1 mg; 5 mg; 50 µL; 100 µL; 250 µL; 5 µmol; 5 x 5 umol; 5 x 50 uL; Custom packaging on request
- Solution concentration
- 4 mM
- Physical form
- aqueous solution
- Stability
- 6 months upon receiving
Application context
- Amine handle in RNA: used as an aminoallyl-modified UTP to introduce a primary amine during in vitro transcription.
- Post-synthetic labeling: the aminoallyl handle can react with amine-reactive reporters such as NHS-ester dyes.
- Ribonucleotide labeling: serves as the RNA-labeling counterpart to aminoallyl-dUTP.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
Frequently Asked Questions
What is 5-aa-UTP used for?
5-aa-UTP is an aminoallyl-modified UTP used to introduce a primary amine into RNA during in vitro transcription for post-synthetic labeling.
How does it differ from aminoallyl-dUTP?
5-aa-UTP is the ribonucleotide version for RNA labeling, while aminoallyl-dUTP is the deoxyribonucleotide version for DNA labeling.
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