2'-FANA-adenosine
(2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- (2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- MF
- C10H12FN5O3
- MW
- 269.23
- Purity
- 99.95%
2'-FANA-adenosine is a 2'F-ANA modified nucleoside: adenosine attached to a 2'-deoxy-2'-fluoro-beta-D-arabinofuranose sugar. Key identifiers include CAS 20227-41-2, molecular formula C10H12FN5O3, molecular weight 269.23, and PubChem CID 11065470.
The 2'F-ANA family uses an arabino C2' configuration, which distinguishes it from ribo 2'-F-RNA. CH70037 should be presented as a modified nucleoside/reference compound for structure and catalog matching, not as a protected CE phosphoramidite monomer.
Synonyms
2'-deoxy-2'-fluoro-arabino adenosine; 2'F-ANA adenosine
Identity and specifications
| Catalog No. | CH70037 |
| CAS No. | 20227-41-2 |
| Molecular Formula | C10H12FN5O3 |
| Molecular Weight | 269.23 |
| Exact Mass | 269.09241742 |
| PubChem CID | 11065470 |
| InChIKey | ZGYYPTJWJBEXBC-GQTRHBFLSA-N |
| Purity | 99.95% |
Storage conditions
-20 C for powder; -80 C in solvent; protect from direct sunlight
Technical attributes
- Material class
- 2'F-ANA nucleoside
- Nucleobase
- Adenine
- Sugar configuration
- 2'-Deoxy-2'-fluoro-beta-D-arabinofuranose
- Protection state
- Unprotected
- Packaging
- 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg; 1 g; 10 mM in DMSO, 1 mL; solid plus solvent kit for 10 mM in DMSO, 1 mL; Custom packaging on request
- Solution concentration
- 10 mM in DMSO
- Physical form
- White solid
- Stability
- 3 years at -20 C for powder; 1 year at -80 C in solvent
Application context
- 2'F-ANA nucleoside reference: an adenosine-bearing 2'-deoxy-2'-fluoroarabino nucleoside for modified-nucleic-acid research.
- Arabino 2'-fluoro chemistry: the arabino C2' configuration distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
- Oligonucleotide chemistry context: use the 2'F-ANA class name and identifiers when matching research catalog records or confirmed internal specifications.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 11065470
PubChem · CID 11065470
Frequently Asked Questions
What is 2'-FANA-adenosine?
2'-FANA-adenosine is a 2'-deoxy-2'-fluoroarabino adenosine modified nucleoside. Its adenosine base and arabino-configured 2'-fluoro sugar are confirmed by PubChem CID 11065470.
How is 2'F-ANA different from ribo 2'-F-RNA?
Both contain a 2'-fluoro sugar modification, but 2'F-ANA has the arabino configuration at C2'. That stereochemical difference distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
Is CH70037 a phosphoramidite monomer?
No. CH70037 is documented as the modified nucleoside 2'-FANA-adenosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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