2'-FANA-guanosine
2-amino-9-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- 2-amino-9-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
- MF
- C10H12FN5O4
- MW
- 285.23
- Purity
- 99.45%
2'-FANA-guanosine is a 2'F-ANA modified nucleoside: guanosine attached to a 2'-deoxy-2'-fluoro-beta-D-arabinofuranose sugar. Key identifiers include CAS 103884-98-6, molecular formula C10H12FN5O4, molecular weight 285.23, and PubChem CID 135434940.
The 2'F-ANA family uses an arabino C2' configuration, which distinguishes it from ribo 2'-F-RNA. CH70039 should be presented as a modified nucleoside/reference compound for structure and catalog matching, not as a protected CE phosphoramidite monomer.
Synonyms
2'-deoxy-2'-fluoro-arabino guanosine; 2'F-ANA guanosine
Identity and specifications
| Catalog No. | CH70039 |
| CAS No. | 103884-98-6 |
| Molecular Formula | C10H12FN5O4 |
| Molecular Weight | 285.23 |
| Exact Mass | 285.08733204 |
| PubChem CID | 135434940 |
| InChIKey | UXUZARPLRQRNNX-AYQXTPAHSA-N |
| Identity Note | PubChem maps CAS 103884-98-6 to multiple stereochemical records; this entry uses PubChem CID 135434940 for the FANA arabino configuration. |
| Purity | 99.45% |
Storage conditions
-20 C
Technical attributes
- Material class
- 2'F-ANA nucleoside
- Nucleobase
- Guanine
- Sugar configuration
- 2'-Deoxy-2'-fluoro-beta-D-arabinofuranose
- Protection state
- Unprotected
- Packaging
- 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg; 1 g; Custom packaging on request
- Physical form
- White to off-white powder to crystals
- Stability
- 3 years at -20 C for powder; 1 year at -80 C in solvent
Application context
- 2'F-ANA nucleoside reference: a guanosine-bearing 2'-deoxy-2'-fluoroarabino nucleoside for modified-nucleic-acid research.
- Arabino 2'-fluoro chemistry: the arabino C2' configuration distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
- Oligonucleotide chemistry context: use the 2'F-ANA class name and verified identifiers when matching research catalog records or confirmed internal specifications.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 135434940
PubChem · CID 135434940
Frequently Asked Questions
What is 2'-FANA-guanosine?
2'-FANA-guanosine is a 2'-deoxy-2'-fluoroarabino guanosine modified nucleoside. PubChem maps the CAS to multiple stereochemical records; this page uses CID 135434940 for the FANA arabino configuration.
How is 2'F-ANA different from ribo 2'-F-RNA?
Both contain a 2'-fluoro sugar modification, but 2'F-ANA has the arabino configuration at C2'. That stereochemical difference distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
Is CH70039 a phosphoramidite monomer?
No. CH70039 is documented as the modified nucleoside 2'-FANA-guanosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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