2'-FANA-uridine
1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- MF
- C9H11FN2O5
- MW
- 246.19
- Purity
- 98.36%
2'-FANA-uridine is a 2'F-ANA modified nucleoside: uridine attached to a 2'-deoxy-2'-fluoro-beta-D-arabinofuranose sugar. Key identifiers include CAS 69123-94-0, molecular formula C9H11FN2O5, molecular weight 246.19, and PubChem CID 3007908.
The 2'F-ANA family uses an arabino C2' configuration, which distinguishes it from ribo 2'-F-RNA. CH70041 should be presented as a modified nucleoside/reference compound for structure and catalog matching, not as a protected CE phosphoramidite monomer.
Synonyms
2'-deoxy-2'-fluoro-arabino uridine; 2'F-ANA uridine
Identity and specifications
| Catalog No. | CH70041 |
| CAS No. | 69123-94-0 |
| Molecular Formula | C9H11FN2O5 |
| Molecular Weight | 246.19 |
| Exact Mass | 246.06519962 |
| PubChem CID | 3007908 |
| InChIKey | UIYWFOZZIZEEKJ-PXBUCIJWSA-N |
| Purity | 98.36% |
Storage conditions
-20 C or 4 C for powder; -80 C or -20 C in solvent
Technical attributes
- Material class
- 2'F-ANA nucleoside
- Nucleobase
- Uracil
- Sugar configuration
- 2'-Deoxy-2'-fluoro-beta-D-arabinofuranose
- Protection state
- Unprotected
- Packaging
- 100 mg; 200 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 10 mM x 1 mL in DMSO; Custom packaging on request
- Solution concentration
- 10 mM in DMSO
- Physical form
- Solid
- Stability
- 3 years at -20 C or 2 years at 4 C for powder; 6 months at -80 C or 1 month at -20 C in solvent
Application context
- 2'F-ANA nucleoside reference: a uridine-bearing 2'-deoxy-2'-fluoroarabino nucleoside for modified-nucleic-acid research.
- Arabino 2'-fluoro chemistry: the arabino C2' configuration distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
- Oligonucleotide chemistry context: use the 2'F-ANA class name and identifiers when matching research catalog records or confirmed internal specifications.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 3007908
PubChem · CID 3007908
Frequently Asked Questions
What is 2'-FANA-uridine?
2'-FANA-uridine is a 2'-deoxy-2'-fluoroarabino uridine modified nucleoside. Its uridine base and arabino-configured 2'-fluoro sugar are confirmed by PubChem CID 3007908.
How is 2'F-ANA different from ribo 2'-F-RNA?
Both contain a 2'-fluoro sugar modification, but 2'F-ANA has the arabino configuration at C2'. That stereochemical difference distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
Is CH70041 a phosphoramidite monomer?
No. CH70041 is documented as the modified nucleoside 2'-FANA-uridine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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