2'-O-Propargyl-2-amino-adenosine
(2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- (2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
- MF
- C13H16N6O4
- MW
- 320.30
- Purity
- >=95%
2'-O-Propargyl-2-amino-adenosine is a modified nucleoside with a 2,6-diaminopurine base and a 2'-O-propargyl sugar substituent. Key identifiers include CAS 1451256-04-4, molecular formula C13H16N6O4, molecular weight 320.30, and PubChem CID 102339225.
The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in clickable sugar-residue and click-compatible oligonucleotide research contexts. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.
Synonyms
2'-O-propargyl-2-aminoadenosine; 2'-O-propargyl-2,6-diaminopurine riboside
Identity and specifications
| Catalog No. | CH70065 |
| CAS No. | 1451256-04-4 |
| Molecular Formula | C13H16N6O4 |
| Molecular Weight | 320.30 |
| Exact Mass | 320.12330301 |
| PubChem CID | 102339225 |
| InChIKey | AGYDCNMIAHDTSH-WOUKDFQISA-N |
| Structural Note | 2,6-diaminopurine nucleoside with a 2'-O-propargyl sugar modification |
| Purity | >=95% |
Technical attributes
- Material class
- 2'-O-propargyl nucleoside
- Nucleobase
- 2,6-Diaminopurine
- Sugar modification
- 2'-O-propargyl
- Conjugation handle
- Terminal alkyne
- Packaging
- Custom packaging on request
Application context
- Clickable sugar-residue research: literature reports 2'-O-propargylated 2-aminoadenosine in oligonucleotides with clickable sugar residues and bifunctional azide chemistry.
- Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for click-compatible oligonucleotide research workflows.
- Modified-nucleoside reference: use as a structure and identifier reference for 2'-O-propargyl 2-aminoadenosine chemistry.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 102339225
PubChem · CID 102339225
Frequently Asked Questions
What is 2'-O-Propargyl-2-amino-adenosine?
It is a modified nucleoside: a 2,6-diaminopurine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 1451256-04-4 under stereospecific CID 102339225.
What does the propargyl group add?
The 2'-O-propargyl group provides a terminal alkyne handle, which is why this type of nucleoside appears in clickable sugar-residue and click-compatible oligonucleotide chemistry studies.
Is CH70065 a phosphoramidite monomer?
No. CH70065 is documented as the modified nucleoside 2'-O-Propargyl-2-amino-adenosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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